成分体内吸收分布特点指导的中药<br /> 药效物质研究探索<br />
Journal Title: Science Paper Online - Year 2006, Vol 1, Issue 4
Abstract
以传统藏药花锚为例，探索了以成分体内吸收分布为指导的中药药效物质研究方法。利用高效液相色谱二极管阵列以及电喷雾质谱检测方法，以及各种色谱分离技术和波谱鉴定手段，从花锚乙醇提取物中分离鉴定了在大鼠肝脏具有高分布特征的8个化合物；并经过抗氧化和体外肝细胞损伤实验证明它们具有一定抗氧化和肝脏保护作用。研究结果表明利用现代灵敏分析检测手段，以天然药物成分的吸收分布特点为指导，进行天然药物成分的研究是一种可行并且值得进行深入探索的方法。
Authors and Affiliations
Jie Gao, Sujuan Wang, Ruiming Xu
Keywords
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