Bridging the importance of Toll like receptors in human viral infections
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2016, Vol 6, Issue 7
Abstract
Toll-like receptors (TLRs) have important role in innate immunity, since they detect pathogenassociated molecular patterns on a wide range of microbes, leading towards activation of innate immune responses and orchestration of adaptive immune response. Most of the viruses have evolved mechanisms to subvert for the benefit of virus and to evade immune system. Literature search was performed from Pubmed and Google Scholar search engines. Among thirteen different types of TLRs, TLR1, TLR2, TLR3, TLR4, TLR7, TLR8 and TLR9 are involved in responses towards viral infection. In this review, we will discuss earlier evidence, mainly from knockout mice studies, implicating TLRs in the innate immune response to viruses, in light of more recent clinical data demonstrating that TLRs are important for anti-viral immunity in humans.
Antimutagenic assay of carotenoids from green algae Chlorococcum humicola using Salmonella typhimurium TA98, TA100 and TA102
Objective: To evaluate the nonmutagenic and antimutagenic properties of the different carotenoids from the selected green algae Chlorococcum humicola (C. humicola) using Ames mutagenicity assay. Methods: Antimutagenicity...
Molecular detection of blood pathogens and their impacts on levels of packed cell volume in stray dogs from Thailand
Objective: To evaluate the prevalence of blood parasite infection in stray dogs by PCR technique and the association between levels of packed cell volume (PCV) and blood parasitic infection in stray dogs. Methods: A tota...
Age associated oxidative damage in RBC and serum of humans
Objective: To evaluate the level of lipid-protein damage and antioxidant status in red blood corpuscle (RBC) and serum of healthy individuals to correlate between oxidative damage with the aging process. Methods: Twenty...
Home-based malaria management in children by women: Evidence from a malaria endemic community in sub-Saharan Africa
Objective: To examine the medicines and dosage that mothers who engage in home-based malaria management administer to children aged ≤ 5 years having signs and symptoms associated with malaria and to discuss the possibili...
Prevalence of glucose-6-phosphate dehydrogenase (G6PD) defiiency in malaria endemic region of Iran (Sistan and Baluchestan Province): Epidemiological profie and trends over time
Objective: To estimate the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in a malarious region of Sistan and Baluchestan Province in south-east of Iran. Methods: A total of 2 997 subjects were selecte...