Brine shrimp lethality assay test, Insilico-molecular Docking studies as a preliminary screening models of some newly synthesized 2-substituted 4,6 dichloro 1,3,5, triazine chalcone hybrids for potential cytotoxic activity
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 3
Abstract
Abstract: An attempt was made in the present study to test for in vivo Brine Shrimp Lethality Assay (BSLT) and molecular docking studies of some newly synthesized 2-substituted 4,6 di chloro 1,3 triazine-chalcone hybrids as potential cytotoxic gents. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). Thirty nauplii were added into three replicates of each concentration of the synthesized compounds. After 24 hours the surviving brine shrimp larvae were counted and LC50 was assessed. Schrodinger Mastero docker was used for insilico molecular docking studies on selected cancer protein Targets. The results drawn from the preliminary studies showed that the compounds TCH-9, 12 and 20, 24 were potent against the brine shrimp with minimum LC50 values of 3.125, and 6.25μg/mL respectively. These findings suggest that the synthesized 1,3,5 triazine chalcone hybrids possess potential cytotoxic activity. Keywords: Brine shrimp lethality assay, LC50, molecular docking, Triazine chalcone hybrids
Authors and Affiliations
Venkata Pavan kumar G, Pooja. Boyapati
Keywords
Related Articles
- EP ID EP390325
- DOI -
- Views 108
- Downloads 0
Surgical Management of Abdominal Wall Defect Using a Two-Stage Latissimus Dorsi Free Flap: A Case Report
Abstract: Managing abdominal wall tumors with high risk of relapse usually requires large excisions. It is the case of sarcomas, desmoid fibromatosis and abdominal wall metastases. The repair of large full-thickness defe...
Relationship of Workload and Working Conditions to Stress Level of Nurse in Intensive Care Unit (ICU)(Pandan Hospital, Tapanuli Tengah, 2017)
Abstract:Stress is a stimulus or a stressful situation. If the situation is a stressful job situation, then stress on work can be caused by several factors, including workload and working conditions. The ICU nurse must m...
To Study Effect of Transversus Abdominis Plane Block Using 0.25% Levobupivacaine on Post-Operative Analgesia in Patients Undergoing Open Prostectomy
Patients undergoing surgery are most feared of postoperative pain. All the techniques for multimodal analgesia has some or the other side effects. Transversus abdominis plane (TAP) block is newer, effective and comparati...
A Case of Minocycline Induced Buccal Mucosa Hyper pigmentation
Abstract: We present a patient exposed to minocycline for 3 years for treatment of resacea, presenting with disfiguring buccal mucosa hyper pigmentation. Discontinuation of the minocycline resulted in dramatic improvemen...
A methylprednisolone induced hypertension and bilateral pleural effusions as acute adverse effects in a young woman “Yahya Al-Fifi’s Syndrome”
Abstract: We describe a rare case of hypertension and bilateral pleural effusion simultaneously in twenty-two years old otherwise healthy young female in March 2017. The patient presented with an allergic reaction to an...