Bronchoscopic drug injection and cryotherapy combined with atomization inhalation in treatment of tracheobronchial tuberculosis
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 10
Abstract
"Objective To explore the clinical efficacy of bronchoscopic drug injection and cryotherapy combined with atomization inhalation for tracheobronchial tuberculosis (TBTB). Methods From May 2019 to February 2023, 60 patients with TBTB treated in Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine were selected as the study subjects, and were randomly divided into two groups with 30 cases in each group by the central randomization method. The control group received conventional thearpy combined with atomization of anti-tuberculosis treatment, while the observation group received bronchoscopic drug injection and cryotherapy of anti-tuberculosis on the basis of the control group. After 3 months of treatment, sputum negative conversion rate, immune function-related indicators [CD4+, CD8+, adenosine deaminase (ADA)], inflammation-related indicators [γ-interferon (IFN-γ), interleukin-4 (IL-4), erythrocyte sedimentation rate (ESR)], symptom relief time and adverse reactions were compared between two groups. Results After 3 months of treatment, IFN-γ and ESR levels, and symptom relief time in observation group were significantly lower than those in control group (P<0.05), while the sputum negative conversion rate, CD4+, ADA and IL-4 levels were significantly higher than those in control group (P<0.05). The incidence of total adverse reactions in observation group was lower than that in control group (10.00% vs 33.33%, χ<sup>2</sup>=4.812, P<0.05). Conclusion Bronchoscopic drug injection and cryotherapy combined with atomization inhalation of anti-tuberculosis for TBTB has a good clinical efficacy, and it can effectively improve the immune function, relieve the inflammatory response, and reduce the adverse reactions in patients with TBTB."
Authors and Affiliations
XU Yuanlong, FEI Xianshu, TIAN Man
Serum Presepsin and GDF-15 levels in patients with acute myocarditis and their correlation with inflammatory level and cardiac function
Objective To investigate the levels of serum soluble CD14 subtype (Presepsin) and growth differentiation factor 15 (GDF-15) in patients with acute myocarditis and their correlation with inflammation factor levels and car...
Influence of fascia iliaca block under ultrasound on anesthesia placement position and postoperative analgesia in patients with hip fractures
Objective To compare the influence of fascia iliaca block (FIB) under ultrasound and intraspinal anesthesia on anesthesia placement position and postoperative analgesia in patients with hip fractures. Methods A total o...
Current status and perspectives liquid biopsy in the whole-process management of tumor diagnosis and treatment
Effective detection methods play a pivotal role in early identification of cancer signal, thereby enhancing patient survival rates. Liquid biopsy, as a burgeoning non-invasive technology, provides comprehensive tumor inf...
Relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression levels and radiotherapy resistance in non-small cell lung cancer
Objective To analyze the relationship between XRCC1 protein, miR-7, c-erbB-2 gene expression and radiotherapy resistance in non-small cell lung cancer (NSCLC) and their predictive value. Methods From January 2020 to Ju...
Clinical value of machine learning model combining test data and enhanced CT images to predict primary hepatocellular carcinoma
"Objective To investigate the clinical value of machine learning methods for the detection of primary hepatocellular carcinoma (HCC) using laboratory data and enhanced CT imaging. Methods The enhanced CT images and tes...