C - reactive protein as A Marker of Status of Chronic Obstructive Pulmonary Disease (COPD): A Prospective Study from PGIMS, Rohtak
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 10
Abstract
Abstract: In spite of the relation between systemic inflammation and CRP in COPD, only a few studies have assessed the role of CRP in measuring the level of systemic inflammation in COPD to assess the status of disease. The present study was planned to correlate the levels of C-reactive protein as a marker of status of COPD.A total of 100 known patients of COPD, diagnosed on the basis of GOLD guidelines, presenting with moderate acute exacerbation were taken in the study. All of these patients were evaluated at the time of admission, discharge from the ward and at follow-up at six week and levels of CRP were correlated with disease duration, spirometric lung function FEV1, arterial oxygen tension and total leucocyte count to evaluate it as a marker of status of COPD. It correlated significantly positively with TLC and negatively with FEV1and SpO2. CRP at discharge and follow-up showed significant negative correlation with disease duration. However, it did not correlate with age, duration of smoking and pack years. As CRP elevation was also found in the cases where infective exacerbation could not be demonstrated, so it may be a marker for non-infective exacerbation also. CRP is an important biomarker in COPD to evaluate the status of disease. It is a useful and early marker of the exacerbation and is also beneficial in assessing efficacy of treatment. Thus, CRP estimation should be a routine investigation in COPD patients to know the baseline level, indication of exacerbation and response to therapy in each patient. Keywords: C-reactive protein, COPD, marker, spirometry
Authors and Affiliations
Vipin Goyal, Yuthika Agrawal, Rajesh Gupta, Veena Gehlaut, Abhishek Singh
Keywords
Related Articles
- EP ID EP372243
- DOI -
- Views 42
- Downloads 0
Parotid Gland Tissue Herniation through the Opening of Parotid Duct after Blunt Trauma on the Cheek
Oropharyngeal injuries are common especially in children. The parotid gland contains several vital structures, all of which may have been damaged causing high morbidity. We present infant boy with parotid gland tissue he...
Laparoscopic Evaluation of Adnexal Masses in Reproductive Age Group
Adnexal masses are one of the most common pathologies among women of all age groups. The aim of the present study was to study laparoscopic diagnosis of adnexal masses in the reproductive age group and to study the spect...
Study of Autonomic Functions- Hert Rate and Blood Pressure in Normotensive, Young Healthy Offspring of Hypertensive Parents and Normotensive Parents
Abstract: Essential hypertension is a 'silent killer' and a major health challenge in all countries of the World. The purpose of study was undertaken to identify early autonomic dysfunction in individuals with parental h...
Acute Intestinal Obstruction Due To Gangrenous Sigmoid Volvulus: A Case Report
Sigmoid volvulus is an unusual but an important cause of intestinal obstruction. It is associated with a high mortality especially when there is delayed diagnosis or when there is presence of gangrenous changes. The inci...
Study on Prevalence of Anxiety Neurosis among the Geriatric Population in Urban Chidambaram
Old age is a part of human development and it is the final phase of the life cycle. The somatic changes and failure to adapt during any time of life cycle can result in physical and emotional illness such as depression,...