C-Reactive Protein in Thrombotic Stroke
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background: Stroke remains a major cause of human mortality and morbidity. Patients with stroke constitute 15- 20% of all admissions in medical college in spite of our increasing knowledge in the pathophysiology and epidemiology. Traditional risk factors like hypertension, diabetes obesity and smoking do not fully account for clinical occurrence of stroke in different population. Indeed atherosclerosis is accepted now as an inflammatory/infectious disease1 . William. Osler in 1908 proposed that infection could be a causal factor in pathogenesis of atherosclerosis. Various microorganisms had been implicated as a potential link between the inflammation and pathogenesis of atherosclerosis, possible infections include Pylori, CMV, Herpes Simplex and Chlamydia pneumonia .Researches found that C-reactive protein is elevated several years before the first episode of stroke. Ridker etal2,3 in 1994 showed 3 fold increase in stroke in CRP elevated patients in a study of 1086 subjects.CRP measurement provide a novel method to detect worrisome level of atherosclerosis in otherwise normal patients. Antimicrobial and antiviral therapy may someday be a part of arsenal of therapy to prevent stroke.4 Limited studies are done in India correlating CRP with thrombotic stroke. Objective 1. To study the C-Reactive protein rise in thrombotic stroke in subjects without traditional risk factors. 2. To identify existence of infection/inflammation in pathogenesis of stroke. 3. To study the correlation of serology Ig GH.pylori infection in CRP positive stroke. Materials and Methods: 200 subjects with first episode of stroke were taken for study. Subjects with CT proven thrombotic stroke without traditional risk factors were selected. These patients were evaluated for CRP levels (the study group). Age and sex matched normal control subjects were selected. All CRP positive stroke patient were screened for Ig-G H.Pylori. Results: Out of 200 subjects with first episode of stroke 150 Subjects with CT proven thrombotic stroke were detected. Of the 150 subjects with CT proven ischemic stroke,80 pat ients were without traditional risk factors (the study group). In the semales constitute 60% and 22 were below age of 40(young stroke). CT findings showed majority of infarct were in basal ganglia and internal capsule. 64 out of 80 ischemic stroke patients had positive CRP (X2= 22.88, p <0.001). 42 out of 64CRP positive patients were found seropositive for Ig-G H.Pylori. Conclusion: C-Reactive protein was significantly elevated in patients with thrombotic stroke without traditional risk factors. Strong correlation between CRP positivity and seroprevalence of IgG H.Pylori.
Authors and Affiliations
Padmakumar Rajasekhara Pillai
Keywords
Related Articles
- EP ID EP284824
- DOI -
- Views 68
- Downloads 0
Antimicrobial resistance pattern of ESBLs producing uropathogenic E. coli (UPEC) in hospitalized patients from a tertiary care hospital of central India
Detection of ESBLs producing organisms from samples such as urine represents an epidemiologic marker of colonization. Thus the present study was aimed to know the antimicrobial resistance pattern among ESBL producing uri...
Metastatic Malignant Melanoma to Bone Marrow with Occult Primary – A Case Report
Background: Metastases of malignant melanoma to the bone marrow are very rare. A few case reports are published in the literature with a known primary site. Herein we report a case of metastatic malignant melanoma in bon...
Adhesive Capsulitis with Cervical Spondylosis, with Physical Therapy Interventions- An Evidence Based Case Study
Introduction: Rotator cuff lesion, a common clinical entity, mostly present with cervical spine lesion, physiotherapy plays a vital role in rehabilitation of these subjects. Aims and Objectives: This case presentation wa...
Microcytic red cell morphology in Dhodia Patel Community: Is there α-thalassemia?
Microcytic red cell indices are commonly associated with iron deficiency anemia (IDA) and β-thalassemia. If these causes are ruled out then there is a possibility of α-thalassemia [1]. α–thalassemia is caused by impaired...
Immunohistochemical Analysis & Correlation of EGFR and Ki-67 Expression Status with Clinicopathological Parameters in Head and Neck Squamous Cell Carcinomas: An Indian Perspective
Head and neck squamous cell carcinoma (HNSCC) is sixth most common neoplasm worldwide and despite the progress made in the diagnosis and treatment, the survivalof these patients has not improved significantly[1] . Theref...