CA15-3 ANTIGEN AS EARLY DIAGNOSTIC AND/OR PROGNOSTIC MARKER FOR MALIGNANT BREAST TUMOUR: A PROSPECTIVE STUDY DONE IN TERTIARY CARE CENTRE BIHAR
Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2017, Vol 3, Issue 1
Abstract
Abstract: Background: This study was done to investigate the association between tumor markers cancer antigen 15-3 (CA 15-3) and clinic-pathological parameters and patient outcomes in breast cancer i.e.to evaluate its diagnostic and prognostic potential. Materials and methods: A total of 148 patients with breast lump either benign or malignant had pretreatment CA 15-3 concentration measured. Univariate and multivariate analyses were used to investigate associations between marker concentration and clinic-pathological parameters and patient outcomes. Results: Among 148 patients, elevated preoperative levels of CA 15-3 identified in 41 (28%). Tumor size (>5 cm), node metastases (≥4), and advanced stage (≥III) were associated with higher preoperative levels. Elevated CA 15-3 was associated with poor prognosis along with significant diagnostic potential of ca15-3 for breast carcinoma. Conclusion: High CA 15-3 level may reflect tumor burden and is associated with advanced disease and poor outcome but not a good diagnostic marker for early disease. Measuring preoperative levels of CA 15-3 can be helpful for predicting outcome.
Authors and Affiliations
Simi Kumari, Sangeeta Pankaj, Richa Madhawi, Jaya Kumari, Syed Nazaneen, Vijayanand Choudhary, Seema Devi, Dinesh Kumar Sinha, Anjili Kumari, Anita Kumari, Rajesh Kumar Singh
Keywords
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