Caffeine as A Catalyst for A Four-Component Synthesis of Dihydropyrano [2, 3-C]Pyrazoles in Water
Journal Title: To Chemistry Journal - Year 2019, Vol 2, Issue 0
Abstract
We describe a one-pot four component synthesis of pyrano[2,3-c]pyrazoles from hydrazine hydrate or phenyl hydrazine, ethyl acetoacetate, an aldehyde, and malononitrile in the presence of catalytic amounts of a caffeine as a green catalyst in water at 50 ºC. The present protocol offers the advantages of a clean reaction, a short reaction time, a high product yield, and an environmentally-friendly, easily-purified, and economically-available catalyst.
Authors and Affiliations
Mohammad Bakherad, Amir H Amin, Rahele Doosti
Keywords
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