Influence of Particle Size on the Anticonvulsant Activity of Propoxazepam
Journal Title: To Chemistry Journal - Year 2019, Vol 2, Issue 0
Abstract
The granulometric composition of new analgesic substance (7-bromo-5-(o-chlorophenyl)-3-propoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one) was characterized by methods of crystals microscopy and lazer diffraction,. The single polymorphic phase demonstrated by differential scanning calorimetry, X-ray diffraction analysis, Raman and IR-spectroscopy. On the base of the anticonvulsive effect on mice in compare to coarse сcrystalline sample the conclusion about the higher pharmacological effect for the disperse sample had been demonstrated.
Authors and Affiliations
Anatoliy Reder, Vitalii Larionov, Nikolay Golovenko, Sergey Andronati
Keywords
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