Can promethazine in combination with sub-analgesic doses of fentanyl offer an alternative to pethidine in pain management? – An experimental study
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2017, Vol 4, Issue 2
Abstract
Introduction: Narcotics like morphine or pethidine are neither widely prescribed, nor readily available as analgesic drugs. Availability of fentanyl is relatively easier, but has tolerability issues and dependence liability. In post-operative setting, fentanyl and promethazine are frequently co-administered. This study aimed at determining the analgesic potential of promethazine in suitable mice models and at studying if combining it with fentanyl could produce analgesia comparable to pethidine, while reducing the dose requirement of fentanyl. Materials and Method: Dose escalation studies were done to determine subanalgesic doses of fentanyl and analgesic potential of promethazine. Subsequently, analgesia by promethazine in combination with sub-analgesic fentanyl was compared to that caused by pethidine. Five groups of mice were evaluated before and after analgesic dosing. Group I served as vehicle control, Group II received pethidine, Group III and IV received combination treatments with promethazine and sub- analgesic doses of fentanyl, Group V received fentanyl. Evaluation of analgesia were done by tail flick analgesiometer and formalin test. Results: Formalin test ratings showed equivalent scores in the pethidine group and fentanyl-promethazine combination groups. Tail-flick latency in the fentanyl-promethazine combination groups was significantly increased in comparison to the pethidine group. When promethazine was combined to sub-analgesic fentanyl, Tail-flick latency was also found to be similar to that of full analgesic dose of fentanyl. Conclusion: The study showed that promethazine had notable analgesic activity in mice. When combined to sub-analgesic doses of fentanyl, promethazine produced better analgesia as compared to pethidine. Combining promethazine to fentanyl reduced the dose requirement of fentanyl without compromising the analgesic efficacy.
Authors and Affiliations
Suvajit Das, Debatri Biswas, Chiranjib Bagchi, Kaushik Mukherjee, Santanu K. Tripathi
Keywords
Related Articles
- EP ID EP295634
- DOI 10.18231/2393-9087.2017.0021
- Views 64
- Downloads 0
An audit of outpatient prescriptions and drug use pattern at a tertiary care centre of Central India
Objective A cross sectional observational survey to assess the drug use pattern and habit of writing rational prescription followed by a feedback to the prescribers to ensure the best practice in writing prescriptionsMat...
Prescribing trends of drugs and WHO core indicators among patients of psoriasis in a tertiary care teaching hospital
Background: The trends of prescribing drugs in patients of psoriasis with an emphasis on WHO core prescribing indicators have never been studied previously in India. Hence the present study was planned to analyse the pre...
Use of Proton Pump Inhibitors – A drug utilization study
Background: In 2006 PPI was the third most frequently prescribed drug in Australia. In United States, UK and New Zealand similar trends were observed. Utilization of proton pump inhibitors is increasing continuously. Dif...
Impact of educational intervention on knowledge and attitude about rational use of medicine among doctors doing internship
Introduction: Rational use of medicine(RUM) include prescribing correct medication, dose, duration of treatment at correct cost. Intern doctors are most prone to prescribing errors, yet are expected to perform a signific...
Evaluation of anxiolytic activity of rousvastatin in male albino mice
Objectives: To assess the anxiolytic activity of ROUSVASTATIN in male albino mice. To compare the anxiolytic activity of ROUSVASTATIN with standard drug as diazepam. Materials and Methods: The study was conducted in Phar...