Can serum lactate dehydrogenase be used as a disease severity biochemical marker in rheumatoid arthritis?
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Introduction:Serum lactate dehydrogenase (S.LDH) is raised in many inflammatory disorders. Rheumatoid arthritis (RA) is a systemic inflammatory disease; S.LDH is expected to rise according to the severity of the disease. Synovial fluid total LDH and its isoenzymes are increased in RA as per some studies. The aim of the present study was to check synovial fluid LDH hypothesis in systemic circulation by testing total S. LDH level in RA patients and correlating it with the severity of the disease. Methods: We have done a cross-sectional study of total 49 patients of rheumatoid arthritis after excluding cases of megaloblastic anaemia, malignancies, liver failure, cardiac failure, renal failure, severe osteoporosis, thyroid disorders and age below 18 years. CDAI and DAS 28 CRP were calculated, serum LDH level more than 3 times of mean normal value (288 IU) was considered as significantly raised. Results and conclusion: Out of a total 49 patients 32 (65.31%) were female and themean age of the patient was 49.35 ± 7.75. As per CDAI Score, 22 (44.90%) patients were having a moderate disease with mean S.LDH of 485.03 IU and 27 (55.10%) patients were having severe disease with mean S. LDH 418.63 IU. As per DAS 28 CRP index 33(67.35%) patients were having moderate disease activity with mean S. LDH 445.37 IU and 16 (32.65%) patients were having severe disease with mean S.LDH of 454.35 IU. Serum LDH has no proportional rise in comparison to the severity of the disease. There is no correlation between ‘DAS 28 CRP’ and ‘mean LDH’ (r = -0.0406, p-value=0.7816); and ‘CDAI’ and ‘mean LDH” (r = -0.2017, p-value=0.1645). Total serum LDH is not a useful biochemical disease severity marker of RA.
Authors and Affiliations
Dhruvkumar M. Patel, Dr. Mukundkumar V. Patel, Akash D. Patel, Greshaben R. Patel, VahinM. Patel, Maitri M. Patel
Keywords
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