Species Distribution and Antifungal Drug Susceptibility of Candida in Clinical Isolates from a Tertiary Care Centre at Bareilly
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Background: The incidence of fungal infections has increased significantly, causing increased morbidity and mortality. The important factor for increased incidence of fungal infections is the overuse of broad spectrum antibiotics for the treatment of multidrug resistant bacteria.. Candida is the major fungal pathogen that causes both mucosal and deep tissue infections. Aim:The aim of our study is to identify the Candida species among clinical isolates and their sensitivity pattern for the common antifungal drugs. Material and methods: Eighty nine different clinical isolates of Candida species were collected from patients admitted in the I.C.U. from 15 jan 2016 to 15 july 2016. The identification of fungal species as well as antifungal sensitivity testing was performed with Vitek 2 compact ( Biomerieux France) using Vitek 2 cards for identification of yeast and yeast like organisms. (ID YST Card). Antifungal susceptibility test was performed with Vitek 2 Fungal susceptibility card (AST YSO7) kit respectively. Result: In this study we found 31.46% isolates were Candida albicans and 68.53% isolates were of non albicans candida. The sensitivity pattern of Candida for various antifungal drugs was fluconazole 86.51%, voriconzole 95.50%, caspofungin 93.28%, micafungin 93.28%, amphotericin B 91.01% and flucytosine was 89.88%. Resistance pattern was more in Candida tropicalis species. Candida krusei was found resistance to fluconazole and voriconazole. Conclusion: Species level identification and their antifungal sensitivity should be performed to achieve their better clinical results.
Authors and Affiliations
Seema Gupta, Rahul Kumar Goyal
Keywords
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- EP ID EP588453
- DOI 10.9790/0853-1601025761
- Views 44
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