Carbamazepine Induced Steven Johnson Syndrome: A Case Report
Journal Title: International Journal of Allied Medical Sciences and Clinical Research - Year 2014, Vol 2, Issue 2
Abstract
Drugs are the most common cause that induces Steven Johnson syndrome (SJS) and includes antiepileptic drugs, antiretroviral drugs, anti-tuberculosis drugs, Sulphonamides, fluoroquinolones, penicillins, non-Steroidal anti-inflammatory drugs, Multivitamins. The genetic markers are also the cause for carbamazepine induced Steven Johnson Syndrome. In our study, the antiepileptic drug (Carbamazepine) is the cause for Steven Johnson Syndrome. A female patient aged 25 years came to the hospital with the complaints of bubbling over the skin and all over the body with papillary vesicles associated with pain and irritation, fever, myalgia, and nausea. The patient is known case of Phenytoin induced Steven Johnson Syndrome. In this case the patient developed the Steven Johnson Syndrome approximately after one month after starting the carbamazepine.By the withdrawal of the drug, the condition of the patient was improved. Recent publications and post- marketing data suggest that Carbamazepine (CBZ) associated SJS/TEN occurs at a higher rate (about 2.5 cases per 1,000 new exposures) in Asian populations.
Authors and Affiliations
Sree Nagavalli K
Keywords
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