“Cardiac Hepatopathy”: A Review of Liver Dysfunction in Heart Failure
Journal Title: Liver Research – Open Journal - Year 2015, Vol 1, Issue 1
Abstract
The unique dual circulation of the liver confers relative protection against ischemic injury; however, low oxygen tension in the microcirculation (sinusoidal blood of the hepatic acinus) may render hepatocytes in zone 3 relatively vulnerable to ischemic injury and necrosis. Severe congestive heart failure is associated with two distinct forms of liver dysfunction under the umbrella term “cardiac hepatopathy”. The two entities include: jaundice related to passive congestion (congestive hepatopathy from backward cardiac failure) and acute hepatocellular necrosis caused by impaired hepatic perfusion (hypoxic hepatitis from forward cardiac failure). This article provides a comprehensive, up-to-date review on the topic and focuses on the epidemiology, pathology, pathogenesis, clinical manifestations, diagnostic testing and treatment strategies pertaining to liver disease in circulatory failure.
Authors and Affiliations
David A. Sass
Keywords
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- EP ID EP556400
- DOI 10.17140/LROJ-1-101
- Views 167
- Downloads 0
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“Cardiac Hepatopathy”: A Review of Liver Dysfunction in Heart Failure
The unique dual circulation of the liver confers relative protection against ischemic injury; however, low oxygen tension in the microcirculation (sinusoidal blood of the hepatic acinus) may render hepatocytes in zone 3...