Cardio protective Effect of Boerhaavia diffusa against Doxorubicin-induced myocardial toxicity in Albino Rats
Journal Title: Scholars Academic Journal of Biosciences - Year 2016, Vol 4, Issue 2
Abstract
Abstract: Doxorubicin is Anrthacycline derivative and most active cytotoxic agent in current use. It is been using to treat various malignancies but the clinical usefulness has been limited due to its specific cardiac toxicity. The main objective is to study the preventive role of ethanolic extract of whole plant of Boerhaavia diffusa (EEBD) against doxorubicin (Dox) induced myocardial toxicity in rats. Cumulative administration of Dox (2.5 mg/kg for two weeks) was injected to produce cardio toxicity. EEBD (100 and 200 mg/kg, po) was administered as pretreatment for two weeks followed by Dox on alternative days for two weeks. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH), Creatine kinase (CK-MB) and cardiac troponin-I (cTnI), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) catalase (CAT) and lipid peroxidation were monitored after three weeks of last dose of Dox. Histopathalogic studies of heart were also carried out to evaluate myocardial toxicity. In results the repeated administration of Dox produces cardiomyopathy, which was characterized by increased level of cardiac biomarkers and deficit antioxidant enzymes. Pretreatment with the EEBD (200mg/kg) significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH, CK-MB and absence of cTnI and biochemical parameters such as AST, ALT and ALP reduced to normal. EEBD increased the reduced level of GSH, SOD and CAT while decreased the elevated level of malondialdehyde (MDA) in cardiac tissue. In conclusion the biochemical and histopathological data evidently substantiate the cardio protective effect of EEBD, which could be attributed to its antioxidant property. Keywords: Antioxidant, cardio toxicity, EEBD, doxorubicin.
Authors and Affiliations
S K Nimbal, B C Koti
Keywords
Related Articles
- EP ID EP372409
- DOI -
- Views 65
- Downloads 0
Pheromones in Animal World: Types, Detection and its Application
Abstract: Animals and humans release masses of biological chemicals in tears, saliva and perspiration. These chemicals used for communication between the organisms are known as semio-chemicals or info-chemicals. Semioche...
The efficacy of Hounsfield unit density of renal calculi in predicting the success of ESWL
Abstract:The outcomes of extracorporeal shock wave lithotripsy (ESWL) depend on several factors and the stone composition has emerged as the main factor influencing the efficacy of ESWL. The density of the stone varies w...
Intra-Oral Mucoepidermoid Carcinoma in a Young Male
Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland malignancies. As its name implies, MEC is composed of a mixture of cells, including mucus producing, epidermoid or squamous and intermediate cells....
Papillary Neoplasms of Breast- Experience at a Cancer Centre in South India
Papillary neoplasms of breast are a rare entity which poses diagnostic challenge to pathologists. There is limited data regarding this entity in Indian population, majority being case reports. Our objective is to evaluat...
Primary Ovarian pregnancy-A rare Case with Review of Literature
Ovarian pregnancy is a rare variant of non tubal ectopic pregnancy with an incidence of around 3 % among all ectopic pregnancies. The diagnosis pre operatively is challenging and is therefore based on intraoperative and...