CARDIOPROTECTION WITH SIMVASTATIN: AN APPRAISAL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Statins, commonly known as 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors are recognized as the foremost drug therapy to show cardioprotection in pathological conditions like dyslipidemia and hyperlipidemia by significantly reducing blood cholesterol levels. Additionally, a number of beneficial effects have been shown by statins apart from lipid lowering that are referred to as their pleiotropic effects. Simvastatin, a potent member of statins class, has been widely used for lowering blood cholesterol levels by inhibiting HMG-CoA reductase both experimentally and clinically. Simvastatin has been well documented to be an effective drug therapy for the treatment of dyslipidemias. In addition, simvastatin has been shown to possess a variety of other pleiotropic effects in way of its potentiality as a cardioprotective agent. The present review critically discusses about the various pleiotropic effects possessed by simvastatin in affording cardioprotection.
Authors and Affiliations
Ankur Rohilla , Seema Rohilla , Gurfateh Singh , Ashok Kumar , M. U Khan
Keywords
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