CARDIOPROTECTION WITH SIMVASTATIN: AN APPRAISAL
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
Statins, commonly known as 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors are recognized as the foremost drug therapy to show cardioprotection in pathological conditions like dyslipidemia and hyperlipidemia by significantly reducing blood cholesterol levels. Additionally, a number of beneficial effects have been shown by statins apart from lipid lowering that are referred to as their pleiotropic effects. Simvastatin, a potent member of statins class, has been widely used for lowering blood cholesterol levels by inhibiting HMG-CoA reductase both experimentally and clinically. Simvastatin has been well documented to be an effective drug therapy for the treatment of dyslipidemias. In addition, simvastatin has been shown to possess a variety of other pleiotropic effects in way of its potentiality as a cardioprotective agent. The present review critically discusses about the various pleiotropic effects possessed by simvastatin in affording cardioprotection.
Authors and Affiliations
Ankur Rohilla , Seema Rohilla , Gurfateh Singh , Ashok Kumar , M. U Khan
Keywords
Related Articles
- EP ID EP103260
- DOI -
- Views 126
- Downloads 0
PHYTOCHEMICALS ANALYSIS AND TLC FINGERPRINTING OF METHANOLIC EXTRACTS OF THREE MEDICINAL PLANTS
The present work is done on three medicinal plants (Enhydra fluctuans, Lecuas aspera and Dillinia indica) in order to investigate the presence of the various types of Phytoconstituents. The leaves of all three plants wer...
IN VIVO ANTI INFLAMMATORY AND ANTI ARTHRITIC ACTIVITY OF ETHANOLIC EXTRACT OF ASPARAGUS RACEMOSUS ROOTS
The present study is aimed to appraise the anti-inflammatory and anti-arthritic activity of ethanolic extract of Asparagus racemosus roots belonging to family Liliaceae. Carrageenan is used to induce inflammation and Fre...
FOURIER TRANSFORM INFRA RED (FT-IR) SPECTRAL STUDIES OF FOENICULUM VULGARE
Plants have been used in traditional medicine for several thousand years. Medicinal plants as a group comprise approximately 8000 species and account for about 50% of all the higher flowering plant species in India. In t...
STUDY ON THE EFFECTS OF VARIOUS DISINTEGRANTS ON AMOXICILLIN TRIHYDRATE DISPERSIBLE TABLETS
The objective of this work was to develop a formulation of amoxicillin trihydrate dispersible tablets of 320mg in a low production value, using cheap amoxicillin trihydrate raw materials available in the market, with dir...
PREPARATION AND EVALUATION OF BIODEGRADABLE ALBUMIN MICROSPHERES OF KETOROLAC TROMETHAMINE
The objective of the present study is to prepare sustained-release ketorolac tromethamine microspheres of bovine serum albumin in different ratios by the emulsion cross-linking method using epichlorohydrin. The prepared...