CARDIOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF CITRUS GRANDIS (L.) OSBECK PEEL ON DOXORUBICIN AND CYCLOPHOSPHAMIDE INDUCED CARDIOTOXICITY IN ALBINO RATS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 4
Abstract
The present study was designed to evaluate the cardioprotective potential of Citrus grandis (L.) Osbeck (CGO) peel extract in rats. Citrus grandis (L.) Osbeck peel extract was evaluated for protection against cyclophosphamide (200 mg/kg body wt., i.p.) and doxorubicin (15 mg/kg body wt., i.p.) induced cardiotoxicity in male albino rats. Biomarkers like lactate dehydrogenase (LDH), alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), total cholesterol (TC), triglyceride (TG) and creatinine kinase (CK-MB) along with heart weight index and antioxidant enzymes was considered to determine the cardioprotective property. Histopathological study was also carried out on heart of experimental animals. The CGO peel extract was found to contain alkaloids, flavonoids, steroids and triterpenoids, saponins, phenolic compounds and tannin as chemical constituents. Cyclophosphamide (CYP) and doxorubicin (DOX) treated groups exhibited significant increase in LDH, ALT, AST, ALP, TC, TG and CK-MB level and decrease in catalase (CAT), superoxide dimutase (SOD) when compared to control group. Pretreatment with different doses of CGO significantly reduced the serum biomarkers and increased the tissue antioxidant level when compared to DOX and CYP alone treated groups. Moreover, treatment with CGO also improved CYP induced changes in histopathology of heart which may be due to its antioxidant property. The Citrus grandis (L.) Osbeck exerted protective effect against CYP and DOX induced cardiotoxicity in rats, which may be due its lipid lowering and antioxidant properties. These findings might be helpful to understand the beneficial effects of CGO extract against myocardial injury although further study is needed to confirm its mechanism.
Authors and Affiliations
Samir Baniya, Dhananjaya D. R. , Ankit Acharya, Bishal Dangi
Keywords
Related Articles
- EP ID EP625079
- DOI -
- Views 77
- Downloads 0
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BENZO THIAZINEN DERIVATIVES
In order to develop relatively small molecules as pharmacologically active molecules, a series of novel oxazolidinones having benzothiazinen and their derivatives were synthesized, and characterized by IR, 1H NMR and Mas...
DETERMINATION OF BIOACTIVE COMPONENTS OF ETHYL ACETATE FRACTION OF PUNICA GRANATUM RIND EXTRACT
Punica granatum belongs to a Punicaceae family. The Punica granatum is valued as a powerful medicinal plant and used in folk medicines. Hence the present investigation was carried out to determine the possible chemical c...
LYSOZYME HYDROCHLORIDE INHIBITS CYTOKINES IN EPITHELIAL CELLS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A BRIEF REPORT
Lysozyme hydrochloride, derived from Hen Egg Lysozyme, is one of classical anti-airway inflammatory drugs. It has been widely administered in Japan, but its molecular potential is unknown. To confirm this classical drug...
OPTIMIZATION AND VALIDATION OF MODULATED RELEASE FORMULATION OF RANITIDINE HCL BY RESPONSE SURFACE METHODOLOGY
The objective of the present study was, 1) to systematically device a model of factors that would yield an optimized sustained release dosage form of model drug (Ranitidine HCl), 2) to validate the models using R2 v...
DESIGN OF EXTENDED RELEASE MATRIX TABLET OF TRAMADOL HYDROCHLORIDE USING COMBINATION OF HYDROPHOBIC AND HYDROPHILIC POLYMER
The aim of design of oral extended drug delivery system is to achieve a prolonged therapeutic effect by continuously releasing medicament over an extended period of time after administration of a single dose. An attempt...