DESIGN OF EXTENDED RELEASE MATRIX TABLET OF TRAMADOL HYDROCHLORIDE USING COMBINATION OF HYDROPHOBIC AND HYDROPHILIC POLYMER
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2017, Vol 9, Issue 5
Abstract
The aim of design of oral extended drug delivery system is to achieve a prolonged therapeutic effect by continuously releasing medicament over an extended period of time after administration of a single dose. An attempt was made to formulate Tramadol Extended Release (ER) matrix tablet using combination of hydrophobic and hydrophilic polymer consisting of ethyl cellulose, HPMC K15M, carbopol, and xanthan gum. The polymeric concentration of hydrophobic and hydrophilic polymer was optimized and was found that drug to polymeric ratio (hydrophobic and hydrophilic) of 1:0.75:0.75 was appropriate for the formulation of Tramadol ER tablet. The concentration of hydrophobic polymer was kept constant were as the combination of hydrophilic polymer was attempted and combined to hydrophobic polymer to retard the drug release for 24-hour from the matrix tablet. A total of nine formulations (F1-F9) of Tramadol matrix tablet, with different concentration of hydrophobic and hydrophilic polymer were used with other excipients. The tablets were compressed by direct compression method after subjecting the blend to blend physical parameters studies like studies like angle of repose, bulk density, tapped density, Carr’s index. The results obtained were satisfactory. Post compression parameters like hardness, weight variation, friability, drug content analysis and in-vitro release profiles of drug from all the formulations could be best expressed by Higuchi’s equation, as the plots showed high linearity (R2: 0.942-0.995). To confirm the diffusion mechanism, the data were fit into Korsmeyer equation. The formulations F-1 to F-6 showed good linearity (R2: 0.961 to 0.993), which indicate the mechanism is diffusion coupled with erosion.
Authors and Affiliations
Sunil Kumar Shah, Prabhakar Bhudholiya, Supriya Pandey, Sujata Kushwaha, Firoz Khan
Keywords
Related Articles
- EP ID EP618307
- DOI 10.25004/IJPSDR.2017.090502
- Views 108
- Downloads 0
A STUDY ON CARVEDILOL VERSUS METOPROLOL IN THE MANAGEMENT OF ATRIAL FIBRILLATION IN POST OPERATIVE CORONARY ARTERY BYPASS GRAFT SURGERY PATIENTS
The objective of the present study is to analyse the effectiveness of carvedilol and metoprolol in the management of atrial fibrillation in post operative coronary artery bypass graft surgery patients. Atrial fibrillatio...
BACTERIOLOGICAL SCREENING OF PAEDIATRIC COUGH SYRUPS MARKETED WITHIN PORT HARCOURT METROPOLIS, SOUTH-SOUTH NIGERIA
Non-adherence to good manufacturing practice alongside improper handling during dispensing, packaging and inadequate post-marketing surveillance of pharmaceutical products accounts to product’s deterioration reduced ther...
OPTIMIZATION AND PRODUCTION OF NEOMYCIN FROM DIFFERENT AGRO INDUSTRIAL WASTES IN SOLID STATE FERMENTATION
The cost of neomycin production may be significantly decreased by using inexpensive carbon substrates like agricultural residues. However, scarce information can be found in the literature about the utilization of cellul...
Formulation and Evaluation of Polyherbal Face Scrubber for Oily Skin in Gel Form
Cosmetics play a vital role for everyone to have a joyful and sanguine life. In present scenario herbal cosmeceuticals have more demand because they have no side effects. People having oily skin suffer from acne, whitehe...
THERAPEUTIC L-ASPARAGINASE ACTIVITY OF BACTERIA ISOLATED FROM MARINE SEDIMENTS
L-Asparaginase, a therapeutic enzyme used in lymphoblastic leukemia and lymphosarcoma chemotherapy which is derived mostly from the bacterial sources Escherichia coli and Erwinia sp. The long term administration of the d...