Cardioprotective effect of a chronic treatment of Ginkgo biloba Phytosomes in isoproterenol-induced cardiac necrosis in rats : Involvement of antioxidant system
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 4
Abstract
The present study investigates the cardioprotective effect and antioxidant activity of a chronic treatment of Ginkgo biloba Phytosomes (GBP) in isoproterenol (ISO) induced cardiac necrosis in rats. Pretreatment of GBP 100 mg/kg daily for 30 & 45 days to rats treated with ISO (85 mg/kg, s.c) on the last 2 days, resulted in a significant cardioprotective activity reflected by attenuation of the ISO-elevated levels of serum marker enzymes (aspartate aminotransferase, lactate dehydrogenase & creatine phosphokinase) and malondialdehyde, and restoration of the activities and levels of the ISO-depleted marker enzymes, reduced glutathione and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase & glutathione reductase) in the heart. However, oral administration of GBP 200 mg/kg to ISO treated rats exhibited lesser cardioprotective effect than GBP 100 mg/kg. It may be concluded that GBP 100 mg/kg oral treatment to ISO challenged rats augments endogenous antioxidants of rat heart, enhances scavenging of free radicals and inhibits lipid peroxidation of membrane, thereby salvaging the myocardium from the deleterious effects of ISO.
Authors and Affiliations
Vandana S. Panda, Suresh R. Naik
Keywords
Related Articles
- EP ID EP49567
- DOI -
- Views 242
- Downloads 0
Anti-microbial and anti-inflammatory flavonoid constituents from the leaves of Lawsonia inermis
A chemical investigation on the leaves of Lawsonia inermis led to the isolation and identification of five known and rare flavonoids, apigenin (1), 5, 7, 4 - trihydroxy-6, 3, 5-trimethoxyflavone (2), pectolinarigenin...
Toxicity evaluation and protective effect of Rhus longipes Engl. leaf extract in paracetamol induced oxidative stress in wister rats
Aim: Acute toxicity and protective effect of ethanol leaf extract of Rhus longipes Engl. against Paracetamol induced oxidative stress was investigated. The LD50 of the leaf extract was determined using up and down tech...
Medicinal plants with anti-inflammatory activity
Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemic...
Amelioration of histological changes and associated metabolic abnormalities by a combination of Morinda lucida and metformin in diabetic rats
This work investigates the ability of Morinda lucida and co-administration of Morinda lucida/metformin in the control of biochemical and histological changes in alloxan-induced diabetic rats. Alloxan diabetic rats were...
Effect of Centella asiatica against anti-tuberculosis drugs-induced hepatotoxicity: Involvement of mitochondria and oxidative stress
The liver is an integral organ in the body and plays a vital role for the metabolism of endogenous and exogenous agents. Drug-induced liver toxicity is one of most common cause of liver injury. It accounts for approxim...