Decoction of Andrographis paniculata whole plant and Gymnema sylvestre leaves demonstrated noteworthy hypoglycemic activity in Sprague Dawley rat
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 1
Abstract
Mother Nature is an elite source for the exploration of leads with good hypoglycemic potential. Progressing in the direction of research, two well-known plants from the Indian subcontinent; A. paniculata (Family: Acanthaceae) and G. sylvestre (Family: Apocynaceae) were chosen and evaluated for their hypoglycemic property in alloxan induced diabetic rat model using metformin hydrochloride as the standard drug. In the current investigation, whole plant decoction of A. paniculata and decoction of G. sylvestre leaves were utilized. The research specified preliminary phytochemical investigations which facilitated better understanding the role(s) of natural bioactive molecules in mediating the activity and their probable mechanism(s). The results represented that the combined decoction of plants significantly exerted the hypoglycemic effect. The glucose lowering activity was mediated by active polyphenol or flavonoid principles present in the decoction which may be believed to enhance the transportation of blood glucose level in the peripheral tissues or via potentiation of insulin secretion from the pancreatic β-cells. The present study reflects the perception to be used clinically according to the toxicity profiles. The research may hold perspective for the development of formulations based on above two natural principles and may open innovative avenues for managing hyperglycemia.
Authors and Affiliations
Sachin P Borikar, Nilesh G Kallewar, Debarshi Kar Mahapatra, Rohit A Gupta, Nitin G Dumore, Kishor R Danao, Ujwala N Mahajan
Keywords
Related Articles
- EP ID EP49784
- DOI -
- Views 195
- Downloads 0
Quality control standardization of the leaves and root of Landolphia owariensis (Apocynaceae)
The leaves and roots of Landolphia owariensis have received much attention for their incredible ethnomedicinal uses and are widely commercialized as aphrodisiac, anti-infective and anti-inflammatory agents in West Afric...
Antidiabetic Herbal Drugs and Polyherbal Formulation Used For Diabetes: A Review
This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. It is caused by the deficiency or ineffective production of insulin by pancreas which results in increase or...
Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia
This study evaluated the acute and subacute toxicity effects of Bridelia ferrugelia leaf extract. Observation of the acute group showed that LD50 of the extract is greater than 2000 mg/kg. The subacute investigation was...
Psychopharmacological studies of Mammea africana stem bark extract
Herbal medicine is an integral part of the health care system in most developed and developing countries of the world. Objective: The stem bark of Mammea africana used traditionally in the treatment of mental disorders...
Anticonvulsant, Anthelmintic and Antibacterial activity of Lawsonia inermis
Lawsonia inermis L. is a branched glabrous shrub or small tree, cultivated for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. In the present study anticonvulsant, a...