Psychopharmacological studies of Mammea africana stem bark extract
Journal Title: The Journal of Phytopharmacology - Year 2014, Vol 3, Issue 3
Abstract
Herbal medicine is an integral part of the health care system in most developed and developing countries of the world. Objective: The stem bark of Mammea africana used traditionally in the treatment of mental disorders was evaluated for depressive effect on the central nervous system (CNS). Materials and Method: The stem bark extract was investigated for depressive activity in the open field, force swimming and tail suspension tests as well as its anticonvulsant potential against pentylene tetrazol and aminophylline-induced convulsions. The effect of the extract on phenobarbitone induced sleeping time was also evaluated. Results: The extract was found to significantly (p<0.001) decrease the frequency of line crossing, rearing and walling activities of the rats in open field test as well as increased the immobility time in both tail suspension and force swimming tests. The stem bark extract also significantly (p<0.001) shortened the onset time of sleep and prolonged the duration of sleep induced by phenobarbitone sodium. The stem bark extract and fractions (30 – 90 mg/kg), could not offered significant protection against PTZand aminophylline induced convulsion, but were found to delay significantly (p<0.05 – 0.001) the onset of tonic/clonic convulsion and also prolonged the time of death of the treated mice. Conclusion: The stem bark of M. africana has depressant, sedating and anticonvulsant properties.
Authors and Affiliations
Jude E. Okokon, Koofreh Davies
Keywords
Related Articles
- EP ID EP49565
- DOI -
- Views 216
- Downloads 0
Effect of Seabuckthorn leaves on Antioxidant and Microsomal Enzymes in poultry birds
In vivo studies on broiler birds were carried out to evaluate effect of aflatoxin and seabuckthorn leaves on microsomal enzyme system, antioxidant enzymes and biochemical parameters i.e. serum triglyceride, total plasm...
Toxicity Evaluation of a Traditional Polyherbal Unani Formulation Jawarish Shahi in Rats
Jawarish Shahi (JS) is a compound polyherbal Unani pharmacopoeial formulation indicated for Khafqan (Palpitation), Nafkh-e-Shikam (Flatulence) and Waswas (Insanity; false perception and hallucinations). Jawarish Shahi...
Sedating property of Ethanolic root extract of Carpolobia lutea in swiss white mice
Carpolobia lutea (C. lutea) is widely used as an alternative medication for varying health disorders. The present study investigated the effect of the ethanolic root extract of this plant, C. lutea on locomotor and exp...
Comparing of anti-inflammatory activity of Sesbania grandiflora and Acacia nilotica on Formalin induced paw edema in rats
Inflammation is defined as the local response of living mammalian tissues to injury due to any agent. It is a body defence reaction in order to eliminate or limit the spread of injurious agent, followed by removal of t...
Phytochemical screening and antimicrobial activity studies of underground bulbs of Ledeboria hyderabadensis
Plants are good source for the bioactive compounds and are used as traditional medicines. Phytochemical investigation of plants emphasizes in traditional medicines has yielded various bioactive compounds with different...