Cardioprotective Effects Of Calcium Gluconate And Dopamine On Acute Propranolol Toxicity In Mice
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Acute beta-adrenergic blocker toxicity is an uncommon complication of acute and chronic cardiac failure treatment. Most acute cardiac toxicity studies use large animals. These studies use rats as animal model by giving propranolol intravenously. This assessed the utility of mice model in acute propranolol toxicity without intravenous cannulation and if calcium gluconate and dopamine can provide cardioprotection. Fifteen male Balb/c mice were assigned to NSS Group (NG; n=5), Calcium Group (CG; n=5) and Dopamine Group (DG; n=5). The NG, CG and DG received normal saline solution, calcium gluconate and dopamine intraperitoneally (i.p.) respectively. Thirty minutes later, propranolol 10 mg/kg BW was given i.p. All mice were observed and the time until demise was noted. Survival rates were presented. Statistical analysis was done using chi-square. Statistical significance was set at p <0.05. All mice in CG group survived with 100% survival rate. The DG mice had 25% survival rate while the NG mice had 33% survival rate. This study showed that calcium gluconate and dopamine given intraperitoneally provided cardioprotection from acute propranolol toxicity. This model of giving propranolol intraperitoneally in mice is a simple method to follow in screening for cardioprotective properties of various natural products.
Authors and Affiliations
Allan L. Hilario
Keywords
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