Cardioprotective Effects of Potassium Channel Openers on Rat Atria and Isolated Hearts under Acute Hypoxia
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2012, Vol 2, Issue 1
Abstract
Under hypoxia, sarcolemmal KATP (sarcKATP) and mitochondrial KATP (mitoKATP) channels exert cardioprotective effects via different mechanisms. In the present study, effects of potassium channel openers (KCOs) on electrophysiology (extracellular field potential, exFP) of the hypoxic heart were measured. During re-oxygenation, the mitoKATP channel opener diazoxide (DZX) reduced the hypoxic effect on the electrophysiology of atria without affecting the exFP duration. DZX also reduced the infarct size of hypoxic hearts (3.01 ± 1.62 %, n = 3). The myocardial cell area changes following KCOs pre-treatment further suggest that DZX-induced cardioprotection in isolated hearts was due to a preservation of cell volume via mitoKATP channel activation. On the other hand, the sarcKATP channel opener pinacidil did not show any significant cardioprotective effect on the heart following hypoxia. The present study demonstrates that the activation of mitoKATP channels may also be involved in cardioprotection following acute hypoxia.
Authors and Affiliations
Law J. K. Y , Yeung C. K , Frisch J , Knapp S , Ingebrandt S , Rudd J. A , Chan M
Keywords
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