CARDIOPROTECTIVE EFFECTS OF SAPONIN Momordica cymbalaria IN ISCHEMIA REPERFUSION INJURY
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 4
Abstract
Momordica Cymbalaria has attracted steady attention in the last few years as phytomedicine possessing a wide spectrum of biological activities. In this study, saponins isolated from Momordica cymbalaria (SMC) was evaluated for global ischemia induced myocardial damage in male Wistar rats and hypoxia ischemia induced cardiocmyotocytes cell death in vitro. Male Wister albino rats were divided into six groups of six animals each and was pretreated with SMC at different doses. To evaluate the efficacy of SMC pretreatment against global ischemia induced myocardial damage, biochemical and histopathological studies were carried out. Ischemia reperfusion injury produced severe myocardial damage and depletion of antioxidant enzymes level. On the contrary, SMC pretreatment reduced myocardial damage by improvement CK-MB and lactate dehydrogenase (LDH). In addition, SMC improved the antioxidant defense system in treated animals and considerably reduced the oxidative stress induced by ischemia reperfusion IR. The reduction in oxidative stress was evident from the lipid peroxidation and enzymatic antioxidant activities. Furthermore, the increase in the levels of CK-MB and LDH in the heart tissue homogenate and the decrease of these enzymes in the perfusate was significantly reversed in the treated groups. The histopathological studies also showed that SMC pretreatment significantly minimized the damage induced by IR. Saponin of Momordica cymbalaria (25mg/kg) provided good cardioprotection against reperfusion induced myocardial infarction in rats compared to higher doses. Pretreatment of rat cardiomyocyte H9c2 cell line with Saponins from Momordica cymbalaria at 20μg/ml was more effective in protecting them from ischemic injury as compared to higher doses confirming the ex-vivo findings that saponin from Momordica cymbalaria provide good myocardial protection at lower doses and show toxic effects at higher doses.
Authors and Affiliations
Mukumbayi P. Mulumba , Raju Koneri , Suman Samaddar
Keywords
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