Cardioprotective function of progesterone: A new perspective
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 2
Abstract
Cardioprotective mechanism in females during reproductive phase is unclear. New perspective explains cardioprotective function of progesterone. Progesterone, the intermediary metabolic product in synthesis of steroid hormones, with t/2 of 30 min, stimulates respiratory center inducing respiratory alkalosis in turn lowers plasma ionic calcium. This results in decreased blood coagulability and cardiac contractility along with smooth muscle relaxation. Vascular smooth muscle relaxation, leading to generalized vasodilatation causes better tissue perfusion resulting in diminished erythropoietin, and erythrocyte count. This reduces blood viscosity and afterload on the heart. Cardiac contractility remains balanced due to opposing influences of decreased plasma ionic calcium and raised basal body temperature. On sudden withdrawal of progesterone, as during premenstrual, postpartum and postmenopausal periods, cardioprotective changes are reversed. The awareness helps to build better body buffer system, aiming to correct acid-base imbalance, during expected fluctuations of progesterone.
Authors and Affiliations
Asha Anand Dharwadkar, Raghuram Ramkumar Chitterusu, Anand Rajendra Dharwadkar, Bindu Balakrishnan Chenmarathy, Kavitarati Anand Dharwadkar
Keywords
Related Articles
- EP ID EP287955
- DOI 10.5455/njppp.2017.7.0927404102016
- Views 88
- Downloads 0
Perception of stress among yoga trained individuals
Background: Yoga, originated thousands of years ago in India, is now well recognized as a form of mind-body medicine. Regular practice of yoga in the form of postures and breathing techniques stabilizes the autonomic ner...
Impact of type 2 diabetes mellitus on short term and working memory
Background: The increase in diabetes among the elderly is of concern because in addition to the wide range of traditional diabetes complications; evidence has been growing that diabetes is associated with increased risk...
Perception of stress in first-year MBBS, BDS, and BPTh students
Background: Stress is a complex dynamic process of interaction between a person and his or her own life. Medical education is perceived as being stressful and characterized by many psychological changes in students. Aims...
Evaluation of cardiovascular autonomic reactivity by cold pressor test in thyroid dysfunction in adults: A prospective case-control study
Background:Changes, in thyroid status, have pronounced effects on cardiovascular system reflecting autonomic dysfunction and increased morbidity. Exact interaction between autonomic nervous activity and thyroid hormones...
Effect of pranayama on respiratory muscle strength in chronic asthmatics
Background: Pranayama is a breathing technique that produces many systemic and psychological effects in the body, specifically on the respiratory system. It is also an art which controls the life force of breath. Aims an...