Cardiotoxicity of Senna occidentalis in sheep (Ovis aries)
Journal Title: Open Veterinary Journal - Year 2016, Vol 6, Issue 1
Abstract
The cardiotoxicity of Coffee senna (Senna occidentalis) was investigated in sheep that were fed diets containing its seeds, which are recognized as the most poisonous part of such weed. Dianthrone, the main toxic component of S. occidentalis, is known to impair mitochondrial oxidative phosphorylation, leading to myofiber degeneration. In this study, fifteen ewes were fed 0%, 2% or 4% of seeds of S. occidentalis for 63 days. Non-specific markers of myocyte injury and electrocardiograms were undertaken at baseline, and at 14, 35, and 63 days after the animals were first fed the diets, while histopathology of heart samples was performed at the very end of the study. Our results showed an increase in serum AST and LDH over time, while CK-MB did not change significantly. Changes that could be ascribed to myocardial damage were not documented in the electrocardiograms. Cardiac histopathology demonstrated only mild-to-moderate vacuolar degeneration, myofiber edema and disarray, structural disorganization, and cellular necrosis. In conclusion, S. occidentalis caused myocardial fiber degeneration in a dose-dependent fashion, but the electrocardiogram was not able to identify these lesions non-invasively. Because the markers of myofiber injury used in this study lack specificity, they may not be used to support cardiac impairment objectively, despite some of them did change over time.
Authors and Affiliations
D. I. S. Lopes| Federal University of Tocantins (UFT), College of Veterinary Medicine and Animal Science, Araguaina, TO, Brazil, M. G. Sousa| Federal University of Paraná (UFPR), Department of Veterinary Medicine, Curitiba, Paraná, Brazil, A. T. Ramos| Federal University of Santa Catarina (UFSC), College of Veterinary Medicine, Curitibanos, Santa Catarina, Brazil, V. M. Maruo| Federal University of Tocantins (UFT), College of Veterinary Medicine and Animal Science, Araguaina, TO, Brazil
Keywords
Related Articles
- EP ID EP9362
- DOI -
- Views 478
- Downloads 28
Exploiting serological data to understand the epidemiology of foot-and-mouth disease virus serotypes circulating in Libya
Sporadic outbreaks of foot-and-mouth disease (FMD) have occurred in Libya for almost fifty years. During the spring of 2013, a countrywide serosurvey was undertaken to assess the level of FMD virus circulation and ident...
Comparison of several methods of sires evaluation for total milk yield in a herd of Holstein cows in Yemen
A total of 956 lactation records of Holstein cows kept at Kaa Albon station, Imuran Governorate, Yemen during the period from 1991 to 2003 were used to investigate the effect of some genetic and non-genetic factors (Si...
Unusual haemodynamics in two dogs and two cats with portosystemic shunt - implications for distinguishing between congenital and acquired conditions
Extrahepatic porto-systemic shunt (PSS) in small animals can be congenital (CPSS) or acquired (APSS) as a consequence of portal hypertension (PH), and are distinguished on the bases of their anatomical pattern. A precis...
Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs
This study was designed to evaluate effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during and after laparotomy in dogs. Eight clinically healthy, adult male dogs, weighing 20 kg wer...
Effects of timed artificial insemination following estrus synchronization in postpartum beef cattle
The objectives of this study were to evaluate estrus response and pregnancy rates resulting from timed artificial insemination (AI) following estrus synchronization using CIDR in postpartum beef cattle. A total of 100 c...