Cardiovascular disease risk factors and its association with subclinical hypothyroidism
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 4
Abstract
Aim: Hypothyroidism is proved to be associated with atherosclerosis and cardio-vascular disease. But correlation between subclinical hypothyroidism (SCH) and increased cardiovascular risk is yet to be established. This study was done to investigate subclinical hypothyroidism and its associations with cardiovascular diseases. Objectives: To quantitatively detect the levels of lipid profile parameters and range of blood pressure, in subclinical hypothyroid and euthyroid subjects. To correlate cardio vascular disease risk factors and their association with subclinical hypothyroidism. Materials and Method: total sixty SCH cases and sixty euthyroid controls were compared. Serums levels of T3, T4, TSH were estimated by standard ELISA kit method, Serum LDL-Cholesterol using Friedewald equation, Triglycerides by GPO-POD with espas method, and Total-Cholesterol, HDL-Cholesterol by enzymatic CHOD-PAP by enzyme colorimetric method. Result: Study showed increased mean serum levels of LDL Cholesterol, Total cholesterol, TSH, Triglycerides, systolic & diastolic BP. Serum levels of T4, HDL-Cholesterol remained normal. Number of people with increased Total Cholesterol, Triglycerides, LDL-C, systolic BP & diastolic BP and decreased HDL-C were more in subclinical hypothyroidism compared to euthyroid cases suggesting the dyslipidemic and hypertensive changes in SCH cases. Conclusion: Study showed that cardio-vascular risk factors are highly associated with hypertension and dyslipidemic state seen in subclinical hypothyroidism cases, suggesting the higher association with subclinical hypothyroidism and risk factors of cardio-vascular disease.
Authors and Affiliations
Smita Kottagi, Triveni Jamble, Srinivas Deshpande
Keywords
Related Articles
- EP ID EP298129
- DOI 10.18231/2394-6377.2017.0099
- Views 57
- Downloads 0
Evaluation of glomerular function in patients with type 2 diabetes mellitus
Background: The leading cause of chronic renal disease and end stage renal disease is diabetic nephropathy, so early recognition is very important. The important biochemical test for diagnosis of renal function is estima...
Early clinical exposure to enhance the learning of biochemistry in first year M.B.B.S students
Introduction Biochemistry is taught using teacher centred method ie lectures where students are passive learners In first year of MBBS students dont feel the importance of biochemistry in clinical practice As a result th...
Perinatal outcome in relation with laboratory findings in pregnancy induced hypertension(PIH)
Background: Perinatal mortality is an important indicator of the status of maternal and child health, the conditions of obstetric care and the level of economic development of a community. The perinatal mortality rate (P...
Serum cholesterol profile in children with celiac disease and effect of gluten free diet
Background: various researchers have shown association of celiac disease with altered lipid profile. We studied serum cholesterol levels in patient with celiac disease and effect of gluten free diet on it. This study aim...
Plasma ascorbic acid levels in patients with subtypes of cataract
Objective: Cataract is a vision impairing disease characterized by gradual, progressive thickening of the lens. It is one of the leading causes of blindness in the world today. Dietary antioxidant vitamins, in particular...