Cardiovascular Diseases and Periodontal Diseases: Review and Update
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 1
Abstract
Accumulated evidence has strongly suggested that the long-term effects of periodontal diseases can be linked to more serious systemic conditions such as cardiovascular diseases (CVD) and diabetes. Especially a prevalence of coronary heart disease is found to be significantly increased in patients with periodontitis after adjusting the risk factors such as smoking, diabetes, and blood pressure. Furthermore, various studies have shown that Porphyromonas gingivalis, a major periodontal pathogen is able to excerbate atherosclerosis following oral-hematogenous spread due to the bacteremia, caused by P. gingivalis, endothelial cells activate various adhesion molecules, thus increasing the likelihood of macrophage diapedesis and subsequent conversion to foam cells and further atheroma progression. These findings indicate the tight relationship between periodontal pathogens and CVD.
Authors and Affiliations
Naba Kumar Pattnaik
Keywords
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