Cardiovascular effects of subclinical thyroid dysfunction
Journal Title: Αρχεία Ελληνικής Ιατρικής - Year 2005, Vol 22, Issue 5
Abstract
Subclinical hyperthyroidism and hypothyroidism are characterized by respectively low or high serum thyrotropin hormone, and normal serum free thyroid hormone levels. Although apparently symptom-free, both conditions have been associated with changes in cardiac structure and function, increased cardiovascular morbidity and possibly mortality. Patients with subclinical hyperthyroidism have been reported to have increased left ventricular (LV) mass, LV diastolic dysfunction at rest and LV systolic dysfunction with exercise. Subclinical hyperthyroidism has been associated with increased mean resting heart rate and a higher incidence of atrial fibrillation in the elderly, similar to clinical hyperthyroidism. Increased cardiovascular mortality in the elderly with subclinical hyperthyroidism has also been reported. Patients with subclinical hypothyroidism have been reported to have LV diastolic dysfunction at rest, systolic dysfunction with exercise, and increased risk for coronary artery disease. Subclinical hypothyroidism is also associated with hyperlipidemia, diastolic hypertension, hyperhomocysteinemia, increased systemic C-reactive protein levels and endothelial dysfunction, and these associations may in part account for the observed association of subclinical hypothyroidism with coronary artery disease. Thyroid hormones exert both direct and indirect actions on the heart and blood vessels, but the precise pathophysiological mechanisms leading to changes in heart function and increased cardiovascular morbidity in patients with subclinical thyroid disease have not been fully elucidated. Restoration of euthyroidism in patients with subclinical abnormalities of thyroid function may improve or reverse some of the cardiovascular abnormalities. Further studies are necessary to fully elucidate the effects of subclinical thyroid disease on the cardiovascular system and establish the efficacy of available treatments in preventing excess cardiovascular morbidity and mortality.
Authors and Affiliations
N. TRITOS, P. DANIAS
Keywords
Related Articles
- EP ID EP123646
- DOI -
- Views 111
- Downloads 0
Acute monoblastic leukemia (M5b) with skin infiltration
A 55-year-old man with a previous history of acute nonlymphoblastic leukemia (AML), which had been treated 14 months earlier and therapy resulted in complete remission, presented with a 2-week history of fatigue, irri...
Intestinal obstruction in a Spigelian hernia with a concomitant jejunal diverticulum
Spigelian hernia (SH) is a rare type of hernia, usually of limited diameter, which commonly presents complications, including incarceration and strangulation of the major omentum and the small or large bowel. The clinica...
Optimization of multiple choice examinations with the use of specifically designed software
OBJECTIVE Multiple choice examinations are often used to assess student achievement. Question's content is chosen mainly by the tutor according to his/her judgment and experience. This project aimed to develop a program...
Work related stress in health care professionals in the economic crisis
OBJECTIVE Evaluation of work related stress in those employed in health care occupations in Korinthia. METHOD The study was conducted in the primary and secondary health care services in Korinthia. The response rate a...
H συχνότητα της υπογλυκαιμίας σε χρόνια αιμοκαθαιρόμενους<br /> μη διαβητικούς ασθενείς κατά τη συνεδρία της αιμοκάθαρσης
ΣΚΟΠΟΣ Οι χρόνια αιμοκαθαιρόμενοι ασθενείς παρουσιάζουν συχνά διαταραχές του μεταβολισμού των υδατανθράκων, οι οποίες προδιαθέτουν σε αυτόματες υπογλυκαιμίες. Σκοπός της μελέτης ήταν η εκτίμηση της συχνότητας και της βαρ...