CD4:CD8 Ratio: A Valuable Diagnostic Parameter for Pulmonary Sarcoidosis
Journal Title: Acta Facultatis Medicae Naissensis - Year 2018, Vol 35, Issue 3
Abstract
Sarcoidosis is a multi-organ disease and is characterized by sarcoidal noncaseating granuloma comprised of T-helper/inducer (CD4+) lymphocytes and scant cytotoxic (CD8+) T-lymphocytes. CD4+:CD8+ T-cell elevated ratio is a characteristic diagnostic parameter for sarcoidosis. This is the first report from Iran evaluating the CD4:CD8 ratio capability in differentiating pulmonary sarcoidosis from other interstitial lung diseases (ILDs) on a large cohort. Fifty pulmonary sarcoidosis patients and 50 non-sarcoidosis interstitial lung diseases (nsILDs) patients were included in the current study. Bronchoalveolar lavage (BAL) was performed using flexible fiberoptic bronchoscopy and flow cytometer. Non-sarcoidosis group was established by 50 components that were classified into eight subgroups. Fifty-two per cent of sarcoidosis patients and 62% of non-sarcoidosis interstitial lung disease patients had normal spirometric results. The CD4/CD8 ratio was significantly higher in sarcoidosis than in non-sarcoidosis interstitial lung diseases (p < 0.001). The CD4/CD8 ratio was found to be > 3.5 in 33.3%, 2.5–3.5 in 7.1%, 1.5–2.5 in 20.2% and < 1.5 in 39.4% of the entire study population. The best cut off point was 1.1 with the sensitivity of 92% and specificity of 80% for distinguishing sarcoidosis from other interstitial lung diseases. Performing bronchoalveolar lavage as the safe and rapid first step confirms the diagnosis of sarcoidosis in 92% of cases (current study sensitivity). Hence, performing an invasive procedure was required in a few patients only. Bronchoalveolar lavage flow cytometry in the assessment of clinical and radiological findings supplies an appropriate diagnostic adjunct for discriminating sarcoidosis from non-sarcoidosis interstitial lung diseases
Authors and Affiliations
Arda Kiani, Ian M. Adcock, Kimia Taghavi, Esmaeil Mortaz, Atosa Doroudinia, Seyed Reza Seyedi, Mehdi Kazempour-Dizaji, ATEFEH ABEDINI
Keywords
Related Articles
- EP ID EP398679
- DOI 10.2478/afmnai-2018-0023
- Views 88
- Downloads 0
External Fixation of Extra-Articular Open Tibial Fractures
External fixation is one of the most commonly used methods for the treatment of open tibial fractures. In everyday practice, for fixation of open tibial fractures we use the external fixator by Mitković. External fixator...
BUBREŽNA DISFUNKCIJA I ISHEMIČNI MOŽDANI UDAR
Hronična bubrežna bolest je važan svetski zdravstveni problem, dok moždani udar predstavlja kontinuirano rastući medicinski i društveni problem. Bubrežna disfunkcija nosi sa sobom značajan rizik za kardiovaskularni morbi...
RAZLOZI ZA EKSTRAKCIJU ZUBA DOBIJENI PUTEM VEŠTAČKE INTELIGENCIJE
Veštačka inteligencija (AI) je nauka koja se bavi projektovanjem inteligentnih mašina, softvera i algoritama. Kompjuterskim praćenjem stomatoloških bolesnika, broj sirovih elektronskih podataka postaje veliki i otvara mo...
ISPITIVANJE EFEKATA RAZLIČITIH EMOLIJENASA NA STRUKTURNA SVOJSTVA KREMOVA I NJIHOV EFEKAT NA VLAŽNOST I PH KOŽE
Ispitivan je uticaj četiri emolijensa (cetearil oktanoat, decil oleat, C12-C15 alkil benzoat i maslinovo ulje) inkorporirana u kozmetički u/v krem, u koncentraciji od 10% (kremovi K1-K4, redom), na strukturna svojstva kr...
AKUTNO-FAZNI SISTEMSKI INFLAMATORNI ODGOVOR KOD BOLESNIKA SA PLUĆNOM TUBERKULOZOM
Osnovni problem kod obolelih od plućne tuberkuloze (PTB) predstavlja nemogućnost imunog odgovora domaćina da ispolji baktericidnu funkciju, te je sterilizacija lezija zavisna isključivo od sprovođenja specifične antimikr...