CEA and CA19-9 in Recurrence and in Monitoring Response in Gastric Carcinoma
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Aim: To analyze the level of serum Carcinoembryonic antigen (CEA) and CA19-9 before and after treatment. Methods: For the study comprising total 60 cases suffering from gastric carcinoma before and after different cycle of treatment were selected. All patients were clinically and histologically diagnosed. A total of 50 age and sex matched healthy subjects taken as control. The circulating levels of CEA and CA19-9 activity were assayed in the in the serum of control group and in patients with Gastric carcinoma. Results: The activity of CEA and CA19-9 was significantly highly increased found in gastric carcinoma patients compare to normal control. In normal healthy control the CEA and CA 19-9 activity was 1.95 ± 0.45, 23.94 ± 9.17 and in patients group 12.52 ± 4.37, 63.93 ± 16.72 respectively and the sensitivity of CEA in gastric carcinoma patients was 31.94 % and CA 19-9 was 42.56%. The combined detection of CEA and CA19-9 had higher sensitivity and specificity in gastric carcinoma patients. The level of CEA and CA19-9 were related to histological type or staging of malignancy. Compared with preoperative concentration, the level of CEA and CA19-9 significantly decreased 4 weeks after treatment or operation. It shows that the tumor is completely removed or a patient gives response to treatment or it shows disease is not recurrence or metastasized. When metastasis and recurrence occurred, the level of CEA and CA19-9 highly significantly increased found. Increased level of Tumor marker like CEA and CA19-9 indicates poorer survival. Conclusion: CEA is a tumor marker that is measured using a blood test.CEA tumor marker is one of the general type tumor markers. A multiply increased CEA levels in the blood indicate to the presence of a malignant disease in the body, but not to the organ in which the malignant change has occurred. High levels of CEA may indicate that cancer has spread; however, other medical conditions and some treatments, including certain types of chemotherapy, may raise CEA levels. The conclusion of the study was that tumor markers can be useful in monitoring the response to treatment and in estimating the prognosis of disease and the combination of CEA and CA19-9 may be useful in diagnosis and management of patients with gastric carcinoma. The various types of biological behaviors of gastric carcinoma need further studies on molecular basis of tumor cells and tumor markers.
Authors and Affiliations
Ranjit S. Ambad
Keywords
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