Cellular functions of p53 and p53 gene family members p63 and p73
Journal Title: Dicle Tıp Dergisi - Year 2011, Vol 38, Issue 4
Abstract
p53 is a transcription factor that regulates multiple cellular processes that are also important in cellular fates such as cell cycle arrest or programmed cell death. Induction of growth arrest or cell death by p53 prevents the replication of damaged DNA and proliferation of genetically abnormal cells. Therefore, inactivation of p53 by mutation or deletion is also important in ensuring the cellular homeostasis. However, studies showed that p53 deficient mice and cells such as Saos-2 cells are maintaining their life. This situation suggests that p53-related proteins might compensate the functions of p53 in p53 deficient organisms. The identification of two p53-related proteins, p63 and p73 revealed the transcription of p53 responsive genes in p53 deficient organisms. Both p63 and p73 proteins have high homology with the p53 protein and share some of the functions of p53. In contrast to p53, p63 and p73 rarely mutated in human cancers. Here we studied to summarize the current information about the p53 and other p53-related proteins, p63 and p73 that are included into the p53 gene family.
Authors and Affiliations
Nadir Koçak, İbrahim Yıldırım, Seval Yıldırım
Keywords
Related Articles
- EP ID EP155674
- DOI -
- Views 113
- Downloads 0
Romatoid artritli hastalarda RANKL, osteoprotegerin ve katepsin-K düzeylerinin kemik mineral yoğunluğu arasında ilişki
Amaç: Bu çalışmanın amacı Romatoid Artrit’li (RA) hastalarda Osteoprotegerin (OPG), Nükleer faktör kappa B reseptör aktivatörü ligandı (RANKL), katepsin-K düzeylerini ve ayrıca bu parametrelerin kemik mineral yoğunluğ...
A questionnaire study about gonadal shield use of urologists
Objectives: Our aim is to reflect routines, awareness, and consciousness level of urologists about usage of gonadal shield (GS) in Turkey. Materials and methods: Because of this objective a questionnaire which includ...
A rare case: Raine Syndrome
Ultrasonography technical developments in the early diagnosis of fetal anomalies in utero has helped. However, a very rare anomaly in utero, or diagnosed late and can be skipped. In this case affect families in a way tha...
The efficacy of albendazole treatment in a patient with hydatid cyst disease of multiorgan involvement
Hydatid cyst disease, which is caused by echinococcus granulosus still poses a serious problem in endemic areas. The disease frequently involves liver and lung. Other organ involvements are rare. In a 18-year old p...
Os trigonum syndrome: A retrospective and comparative study
Objectives: The aim of this study was to evaluate the os trigonum syndrome by magnetic resonance imaging (MRI). Materials and methods: A total of 76 ankle MRI images were evaluated, retrospectively. All MRI examinati...