Specificity and selectivity evaluations of ligand binding assay of protein therapeutics against concomitant drugs and related endogenous proteins

Modeling NSCLC Progression: Recent Advances and Opportunities Available

Non-small cell lung cancer (NSCLC) is one of the leading causes of death around the world with an estimated 5-year relative survival rate of 16% at diagnosis. Development of drugs treating NSCLC is not easy, and the succ...

Modeling Testosterone Circadian Rhythm in Hypogonadal Males: Effect of Age and Circannual Variations

The objective of this study was to characterize the baseline circadian rhythm of testosterone levels in hypogonadal men. A total of 859 baseline profiles of testosterone from hypogonadal men were included in this analysi...

Dopamine D2 Occupancy as a Biomarker for Antipsychotics: Quantifying the Relationship with Efficacy and Extrapyramidal Symptoms

The online version of this article (doi:10.1208/s12248-010-9247-4) contains supplementary material, which is available to authorized users.

Maturation and growth of renal function: Dosing renally cleared drugs in children

A model was developed that characterized the maturation and growth of the renal function parameters (RFPs) glomerular filtration rate (GF), active tubular secretion (AS), and renal plasma flow (QR). Published RFP values...