Pharmacodynamic parameter estimation: Population size versus number of samples

The purpose of this study was to evaluate the effects of population size, number of samples per individual, and level of interindividual variability (IIV) on the accuracy and precision of pharmacodynamic (PD) parameter e...

Corrigendum: Insights into the effects of hyperlipoproteinemia on cyclosporine a biodistribution and relationship to renal function

Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway

The online version of this article (doi:10.1208/s12248-016-9901-6) contains supplementary material, which is available to authorized users.

Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies

In contrast to current pharmacotherapies, immunologic approaches to treating tobacco dependence target the drug itself rather than the brain. This approach involves the use of nicotine-specific antibodies that bind nicot...

The cytoplasmic escape and nuclear accumulation of endocytosed and microinjected HPMA copolymers and a basic kinetic study in hep G2 cells

The development of macromolecules as drugs and drug carriers requires knowledge of their fate in cells. To this end, we studied the internalization and subcellular fate of N-(2-hydroxypropyl)methacrylamide (HPMA) copolym...