Cementum: Composition, Formation and Regeneration
Journal Title: Journal of Clinical Medical Research - Year 2022, Vol 3, Issue 1
Abstract
Cementum is forming a thin layer over the root. Incremental lines of Salter reflect periodic deposition, separating mixed cementum into successive layers. Cementum plays a role in the anchorage of the teeth and adaptative, reparative and regenerative functions. Entrapped in cementum, cementoblasts become cementocytes located inside lacunae. Type I (90%) and III (5%) collagens constitute the major components of the matrix. In addition, non-collagenous proteins include proteoglycans, bone sialoprotein, osteopontin, fibronectin, osteonectin, a2-HS glycoprotein (also named fetuin-A), osterix and non-specific alkaline phosphatase (NSAP). It contains also cementum-specific proteins, a number of growth factors (IGF, FGF, PDGF, TGF b, BMPs and EGF), transcription factors, enamel-associated proteins and tuftelin, involved in the initial stages of enamel mineralization. These molecules contribute to cementum formation, structural and molecular repair and may be used for cementum regeneration.
Authors and Affiliations
Michel Goldberg1*
Keywords
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- EP ID EP700569
- DOI http://dx.doi.org/10.46889/JCMR.2022.3104
- Views 82
- Downloads 0
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