Cerebrospinal Fluid Lactate Concentration to Differentiate Bacterial from Viral Meningitis in Children
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 5
Abstract
Objective: To define an optimal CSF lactate concentration that can be called significant for the differentiation bacterial meningitis from viral meningitis in children. Methods: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. We determined the optimum cutoff point for CSF lactate using receiver-operator curve (ROC) analysis. Results: We identified 54 had bacterial meningitis. Children with bacterial meningitis had а higher median CSF lactate level [6.5 mmol/l, interquartile range (IQR) 2.3-10.7 mmol/l bacterial meningitis vs. 2.1 mmol/l, IQR 1.3-2.9 mmol/l viral meningitis]. А CSF lactate cutoff point of 3.0 mmol/l had а sensitivity of 87.0% (95% CI 66.4 - 97.2%), а specificity of 87.1% (95% CI 70.2 - 96.4%) for bacterial meningitis. The CSF lactate concentration is а better marker compared to other conventional markers including CSF glucose and CSF total number of leukocytes.Conclusion: In combination with а validated meningitis clinical prediction rule, the CSF lactate level can be used to distinguish between bacterial and viral meningitis in children.
Authors and Affiliations
Ton Nu van Anh, Nguyen Huu Son, Mai Thi Hien Uyen, Nguyen Thi Hong Duc, Tran Vinh Phu
Keywords
Related Articles
- EP ID EP587591
- DOI 10.26717/BJSTR.2019.15.002769
- Views 133
- Downloads 0
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