Certain Aspects Of Teratological Effects Of Retinoids On Skin Of Swiss Albino Mice.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Teratology is a branch of Embryology that deals with abnormal development . The development of an organism is a complex process of embryogenesis involved cell proliferation, differentiation, migration and organogenesis. Many agents interfering the development process can cause malformations in the embryo. The study of these congenital abnormalities is called teratology and agents which are responsible for causing these malformations are called teratogens. Susceptibility to teratogens depends on the genotype of the organism, including species as well as strain differences. Etienne Geoffrey Saint Hilaire and his son in 1820 started experiments on chick embryo by disturbing its environment in different ways at different embryonic stages. They found some anomalies like Trioncephally, atrophy of eyes and spina bifida in his experiments (Tuli, 1968). In 1877 Dareste reported found some anomalies like Trioncephally, atrophy of eyes and spina bifida in his Experiments (Tuli, 1968). Retinoids are essential for spermatogenesis oogenesis, placental development, foetal morphogenesis and growth. The role of vitamin A in vision is well known . Active derivative of vitamin A (Retinoids ) play an important and multiple role in Mammalian development and homeostasis (Sapin, et.al. 1997, Dup et al 1997). These essential dietarycompounds are needed in very small quantities, they are not synthesized by the animals and are obtained fromexternal sourcesin the form of b carotene (C40H56). In cells of intestine b carotene is converted intovitamin alcohol and is transported by blood to liver where it is esterfied and stored as vitamin A palmitate. RA is not stored in liver but is derived from retinal and it is biologically the most potent form of vitamin A.Vitamins are organic compounds which are devided into 2 categories i Fat soluble (A,D,E,K)and ii water soluble (B and C).Vitamin A belongs to fat soluble category of vitamins. A fat soluble substance essential for life was first discovered in egg yolk in 1909 by Stepp (Pawson, 1981; Robert and Sporn, 1984). It was confirmed by Mc Collum Devis in 1913 when he found a compound with similar biological activity in butter fats, egg yolk and cod liver oiland was named fat soluble vitamin A. In the present study effects of different doses on skin on different development stages of swiss albino mice are studied.
Authors and Affiliations
Dr Rashmi Sharma1, Ashok Gupta2
Keywords
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