Chagas´disease, BMI, ACEI/D polymorphism interactions and some considerations on the “Obesity Paradox”
Journal Title: International Journal of Medical Science and Dental Research - Year 2019, Vol 2, Issue 2
Abstract
Chagas´ disease (ChD), a parasitic disease widely distributed in Argentina, courses mainly with myocardiopathy due to parasympathetic denervation evolving to right hypertrophy, dilatation, or left insufficiency and dilatation. Chagas´ disease comorbidities include hypertension, cardiac remodeling and obesity. The D allele of angiotensin-converting enzyme (ACE I) gene is associated with similar cardiometabolic imbalances. Though obesity is a risk factor of disease, some studies, have suggested that reduces mortality due to infectious diseases. We discuss whether ChD high BMI may be attributed merely to parasitic damage or to a hypothetic interaction between parasite and ACE I/D polymorphism. DNA was obtained from leukocytes of 79 patients including control and infected individuals of closed and open communities to detect ACE I/D polymorphism, the rest of the sample underwent ELISA for Chagas ´disease and routines for lipids and glucose. Chagas´disease strongly associated with D allele, ≥30 BMI, high LDL cholesterol, creatinine and triglycerides but lower glucose. ≥30 BMI was evenly distributed among DD, I/D and II genotypes. No II patient was infected. ≥30 BMI was not determined by ACE genotype. Since evolution was benign except for one morbid obese and two low BMI patients, overweight, not obesity seems to be protective.
Authors and Affiliations
Sadí Cossy Isasi, Julio César Cosiansi, Susana Keim, Guillermo Giordano, Juan Carlos Muiño
Keywords
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