Modification of Pectin-Glycine with Indomethacin to treatment the wound and inflammations
Journal Title: International Journal of Medical Science and Dental Research - Year 2018, Vol 1, Issue 1
Abstract
This work included preparation new drug polymer as bio adhesive , which have high viscosity and treatment the wounds andexternal inflammation, because it remains inherent to the position of injury fast time, A new bio adhesivepolymer was prepared bymodification of Pectin structure with Glycine as a spacer substituted with drug such as Indomethacinproduced amide polymer. This design carries controlled delivery of therapeutic agents which could release the entrapped drug over an extended period of time due to its biodegradable, nontoxic and slow digesting nature. The prepared drug polymer wsa characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were studied. intrinsic viscosities and Physical properties of all prepared polymer wsa measured, Biological activity was studied for drug polymer,this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave good results and compliance mice infected with a full recovery by a short period of time.
Authors and Affiliations
Firyal Mohammed Ali, Hameed Muthanna Ahmed
Keywords
Related Articles
- EP ID EP514846
- DOI -
- Views 123
- Downloads 0
Effectiveness of Motor Control Exercise on Increasing Functional Ability of Lumbar Joint in Non-Specific Low Back Pain
Non-specific low back pain is a symptom of low back pain that occurs without unknown cause, could result in pain, muscle spasms, and imbalance muscle, and decrease the stability of the abdominal and lower back muscles. M...
Effects of Administering Soft Drinks on Some Biochemical Parameters and Histopathology of Liver in Wistar Rats
The ruling of the Lagos High Court at Igbosere, Nigeria on the 13th March, 2017 gave birth to this research work. The court ordered NAFDAC to enforce the Nigerian Bottling company (NBC) to write warnings on the potential...
Trismus Masquerading Embryonal Rhabdomyosarcomaan extremely rare case report and literature review
Rhabdomyosarcoma was first described by Weber1 in 1854. It is the most common soft tissue sarcoma and malignant orbital neoplasm in infants and children1, 2. It is a rare malignant tumour with extremely aggressive and in...
Impact of Malaria in Pregnancy: Implications on The Fetus and Children
Malaria is a serious public health challenge especially in the developing world like Nigeria. It is more devastating in highly endemic areas like our country. The infection has no age and sex limit but is more felt among...
Cytotoxicity of toothpastes used for gum health
Objective:The aim of this study was to evaluate the cytotoxic effects of 4 different toothpaste on the L929 mouse fibroblast cells.Materials and Methods: Cytotoxicity of Colgate Total Pro Gum Health, Ipana Pro Expert Cli...