Challenges and issues in veterinary pharmacology and animal health 2004—Preface
Journal Title: The AAPS Journal - Year 2005, Vol 7, Issue 2
Abstract
Authors and Affiliations
Marilyn Martinez, Stefan Soback
Marilyn Martinez, Stefan Soback
Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on 18F-2-Fluoro-2-Deoxy-d -glucose (18F-FDG) Brain Kinetics
The fluorinated d -glucose analog 18F-2-fluoro-2-deoxy-d -glucose (18F-FDG) is the most prevalent radiopharmaceutical for positron emission tomography (PET) imaging. P-Glycoprotein’s (P-gp, MDR1, and ABCB1) funct...
A novel method for the determination of biliary clearance in humans
Biliary excretion is an important route of elimination and the biliary tract is a potential site of toxicity for many drugs and xenobiotics. Quantification of biliary excretion in healthy human volunteers is logistically...
Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers
Ethanol significantly increased the permeability of oxycodone, oxymorphone and atenolol in a concentration-dependent (1–5%) manner. The permeability of hydromorphone and metoprolol were not altered by ethanol. Th...
Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer
Intraperitoneal (IP) chemotherapy confers significant survival benefits in cancer patients. However, several problems, including local toxicity and ineffectiveness against bulky tumors, have prohibited it from becoming a...
Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors
The online version of this article (doi:10.1208/s12248-013-9493-3) contains supplementary material, which is available to authorized users.