Changes of retinal nerve fiber layer thickness in patients with different types of angle-closure glaucoma
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 11
Abstract
AIM: To investigate the changes and significance of retinal nerve fiber layer(RNFL)thickness in patients with acute and chronic angle-closure glaucoma. <p>METHODS: Totally 37 patients(40 eyes)with acute angle-closure glaucoma and 35 cases(38 eyes)patients with chronic angle-closure glaucoma in our hospital from January 2016 to January 2018 were studied, and 30 cases with normal check-up in our hospital were compared. All the objects were scanned by optical coherence tomography(OCT). All subjects underwent visual field examination and OCT examination. According to the visual field examination results, the patients were divided into 2 subgroups of visual field defect and normal visual field. To study the relationship between RNFL thickness and visual field defect. <p>RESULTS: The superior, inferior, nasal side and average RNFL thickness of the acute group were obviously higher than that in the normal group(160.41±39.87μm <i>vs </i>124.50±14.86μm, 155.38±31.79μm <i>vs</i> 127.75±20.08μm, 96.12±32.01μm <i>vs</i> 75. 79±13.10μm, 121.49±21.46μm <i>vs</i> 101.79±10.34μm), and the average RNFL thickness of the chronic group was lower than that in the normal group(superior: 91.57±30.22μm, inferior: 96.23±30.68μm, nasal side: 65.46±16.94μm, temporal side: 63.28±16.94μm, average: 80.58±22.18μm; <i>P</i><0.05). The RNFL thickness of the superior and inferior part of normal visual field in the acute group was lower than that of the same group with visual field defect(159.68±27.49μm <i>vs</i> 163.32±37.76μm; 152.31±21.86μm <i>vs</i> 161.27±32.09μm; <i>P</i><0.05); however, there was no significant difference on nasal side, temporal side and average RNFL thickness between the two subgroups(<i>P</i>>0.05). And the RNFL thickness of the subjects in chronic group with visual field defect was significantly lower than that in normal visual field(120.83±13.19μm <i>vs</i> 88.82±25.18μm, 124.83±17.01μm <i>vs</i> 85.89±30.91μm, 76.06±11.79μm <i>vs</i> 62.03±12.13μm, 75.17±9.99μm<i> vs</i> 63.09±8.24μm; <i>P</i><0.05). <p>CONCLUSION: The RNFL thickening of acute PACG is mainly caused by optic nerve edema, while chronic PACG's RNFL thinning is due to the damage of ganglion cells and the loss of nerve fibers, different reasons cause different PACG thickness.
Authors and Affiliations
Zhong-Yan Lai
Keywords
Related Articles
- EP ID EP519537
- DOI 10.3980/j.issn.1672-5123.2018.11.20
- Views 108
- Downloads 0
Clinical analysis of neovascular glaucoma after vitrectomy in patients with diabetic retinopathy
AIM: To explore the factors and analyze the occurrence of neovascular glaucoma(NVG)after vitrectomy for proliferative diabetic retinopathy(PDR). <p>METHODS:Retrospective analysis on the clinical materials from January 20...
Differential expression of adipose-specific phospholipase A2 mRNA in orbital adipose tissue in patients with TAO
AIM:To analyze the difference in the level of fat-specific phospholipase A2(AdPLA)mRNA in the orbital adipose tissue between patients with thyroid-associated ophthalmopathy(TAO)and normal subjects. <p>METHODS:Thirty-seve...
Efficacy of Bevacizumab combined with EX-PRESS in the treatment of refractory glaucoma
AIM:To investigate the efficacy of Bevacizumab intravitreal injection combined with EX-PRESS in the treatment of refractory glaucoma. <p>METHODS: The research objects were 150 cases(150 eyes)of patients with refractory g...
Efficacy of fundus photocoagulation combined with triamcinolone acetonide on diabetic retinopathy
AIM: To observe the efficacy of fundus photocoagulation combined with triamcinolone acetonide(TA)in the treatment of diabetic retinopathy(DR). <p>METHODS: The clinical data of 94 patients(112 eyes)in our hospital from Se...
Efficacy at early stage after FS-LASIK with accelerated corneal collagen cross-linking
AIM:To evaluate the safety and efficacy at early stage after femtosecond laser-assisted excimer laser <i>in situ</i> keratomileusis(FS-LASIK)combined with collagen cross-linking. <p>METHODS: Totally 30 myopia patients(60...