Characteristics of cognitive functions in patients of different age with dyscirculatory encephalopathy and metabolic syndrome
Journal Title: Український неврологічний журнал - Year 2018, Vol 0, Issue 2
Abstract
Objective — to establish the characteristics of cognitive changes in patients of different age subgroups with metabolic syndrome (MetS). Methods and subjects. 503 patients aged 45 to 89 years with dyscirculatory encephalopathy (DE) of mixed etiology were examined. Patients were divided into two groups: 1 — without MetS (n = 198), 2 — with MetS (n = 305). Patients in both clinical groups were also divided into 3 age subgroups: 45 — 59 — middle age, 60 — 74 years — elderly, 75 — 89 years old — senile age. The general‑clinical, neurological, neuropsychological, laboratory and instrumental examinations were conducted. Results. The patients with DE and MetS had worse indicators of cognitive functions, compared to the patients without MetS (the speed of sensory motor responses, mental performance, the volume of active attention, the efficacy of information processing, lower rates on the clock drawing test and the Frontal Assessment Battery). The severity of cognitive decline in patients of both clinical groups accrued with aging. The most pronounced negative effect of MetS on cognitive functions was observed in the subgroup of middle‑aged patients, which was depicted in significantly lower overall MMSE score. According to the MMSE subtest profile, patients with DE and MetS of all age subgroups had significantly worse, comparing with patients without MetS, parameters of the short‑term memory and reproduction of verbal material. It should be noted that in the middle and elderly age, changes in the cognitive profile are similar, whereas in the senile age subgroup it varies due to an increase in deterioration in time orientation subtest paramters. Conclusions. Patients with DE with MetS had more severe impairment of cognitive functions. Significant influence of age on the severity of cognitive impairment was found: the severity of cognitive deficits in patients of both clinical groups increased in aging.
Authors and Affiliations
O. O. Kopchak, N. Yu. Bachynska
Keywords
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- EP ID EP421294
- DOI 10.30978/UNZ2018251
- Views 72
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