Structural changes in the brain at the stage of clinically isolated multiple sclerosis
Journal Title: Український неврологічний журнал - Year 2019, Vol 0, Issue 1
Abstract
Objective — to estimate the brain atrophy in patients with CIS compared to the control group of healthy individuals. Methods and subjects. Observational, transverse, controlled study of atrophic changes in the brain in patients with clinically isolated syndrome of MS was conducted for the first time in Ukraine. 30 patients were included into the study. Control group comprised 29 patients, mean age of patients was 32.07 ± 8.54 healthy individuals‑ — 36.70 ± 2.39 years (р = 0.02). Female patients prevailed in both groups — 27 (90 %) and 18 (62 %) (р = 0.07) respectively. 18 (60 %) patients had multifocal CIS, the rest of patients had monofocal CIS. The EDSS functional scale points were distributed: ocular — 0.833 ± 1.090 points, pyramid — 1.33 ± 0.96 points, cerebellar — 1.33 ± 1.12 points, pelvic disorders — (0, 23 ± 0.63) points, cerebral disorders — 0.17 ± 0.38 points. Total sum was 2.98 ± 0.55 points at the moment of CIS. For evaluation of atrophic processes for each patient and healthy control, measurements of 23 linear parameters were performed and 14 indices for each magnetic resonance imaging were calculated. Results. Early atrophy, found in patients with CIS compared to the control group, occurs predominantly in the gray matter of the brain. Statistically significant difference at the level p < 0, 05 was established for the following indicators: the index of median structures of the brain, the width of the third and lateral ventricles. The index of the corpus callosum, the index of frontal atrophy, Evans and Gukman indeces, as well as the bicaudate index, the ventricular parieto‑occidental index are not sufficiently sensitive in the evaluation of atrophic changes in the brain in patients with clinically isolated syndrome. The mechanism of neurodegeneration starts at the CIS in the initial moments of the disease, it is possible, prior to the clinical manifestation of the disease. Conclusions. It is established that atrophic processes of the brain occur at the stage of the CIS. The indeces of median structures of the brain, the width of the third and lateral ventricles are most sensitive to the evaluation of brain atrophy at the stage of the CIS.
Authors and Affiliations
O. D. Shulga
Keywords
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- EP ID EP594452
- DOI 10.30978/UNJ2019-1-26
- Views 98
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