Characteristics of HIV-infected persons and their spouses who became HIV-positive in HIV discordant couples in Dehong Prefectureï¼ Yunnan Province
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 12
Abstract
ObjectiveTo determine the characteristicsï¼ viral load and immunological status of HIV-infected persons and their spouses who became HIV-positiveï¼ and the reasons for HIV seroconversion in 55 HIV discordant couples in Dehong Dai and Jingpo Autonomous Prefecture ï¼Dehong Prefectureï¼ï¼ Yunan Province.MethodsData on the 55 couples meeting the criteria of having a previously positive spouse were retrieved from the AIDS Integrated Prevention and Control Data Information System of the China Disease Control and Prevention Information System during 2015-2021. General socio-demographic informationï¼ age at diagnosisï¼ exposure historyï¼ CD4+T lymphocyte countï¼ and antiviral treatment were collected. Descriptive analysis and chi-square test were used to compare the distribution of pre-HIV-positive spouses and their HIV seroconverted spouses.ResultsA total of 55 spouses from HIV discordant couples had HIV seroconversion. Of themï¼ 72.7% ï¼40/55ï¼ of pre-HIV-positive spouses were husbands. The most recent CD4+T lymphocyte count in the pre-HIV-positive spouses was ï¼328.31± 246.27ï¼ cells·μL-1 at the time of diagnosis of their seroconverted spousesï¼ of which 36.3% ï¼20/55ï¼ had a CD4+T lymphocyte count of less than 200 cells·μL-1. Furthermoreï¼ of those pre-HIV-positive spouses with low CD4+T lymphocyte countï¼ 45.0% ï¼9/20ï¼ had an undetectable viral loadï¼ 15.0% ï¼3/20ï¼ <400 copies·mL-1ï¼ and 25.0%ï¼5/20ï¼ â¥400 copies·mL-1. Additionallyï¼ 16.4% ï¼9/55ï¼ of the pre-HIV-positive spouses did not have a viral load test. The main reasons for HIV seroconversion among HIV-negative spouses in the discordant couples were poor condom useï¼ poor compliance with antiviral therapyï¼ and treatment discontinuation.ConclusionThe follow-up management of HIV discordant couples should be strengthened in Dehong Prefectureï¼ especially the monitoring of viral load levels and immunological status of pre-HIV-positive spousesï¼ to improve their compliance with antiviral therapy and reduce treatment discontinuationï¼ which would effectively prevent and control HIV transmission between spouses.
Authors and Affiliations
LI Yanling,HE Shuxian,CAO Yanfen,XIANG Lifen,GONG Yurong,YANG Yuecheng,YE Runhua,TANG Renhai,DING Yingying,HE Na,DUAN Song,
Keywords
Related Articles
- EP ID EP742228
- DOI -
- Views 12
- Downloads 0
Surveillance and trend analysis of snails in Songjiang District of Shanghai from 2007 to 2023
Objective To analyze the monitoring results and trends of Oncomelania in Songjiang District of Shanghai from 2007 to 2023， and to provide reference for future monitoring work.Methods The data of snail monitoring in Song...
Trans-fatty acid content in edible vegetable oil under different high temperatures
ObjectiveAn experimental method was established to determine the level of trans-fatty acids in edible vegetable oil and the changes of trans-fatty acid content during high-temperature simulated cooking.MethodsFour common...
Hospitalization costs of road traffic injury in Shanghai，2017‒2020
Objective To assess the direct economic burden and influencing factors of road traffic injuries in Shanghai， providing a basis for future prevention of road traffic injuries.Methods Information of inpatient cases caused...
Isolation of Enterobacteriaceae strains carrying mcr-1 resistance gene from Shanghai wastewater treatment plants and quantification of their copy number
Objective To provide technical support for the molecular surveillance of pathogenic bacteria strains carrying mobile colistin resistance-1 （mcr⁃1） gene isolate from inlet of wastewater treatment plants （WWTP）.Methods...
A study of factors influencing the willingness of primary healthcare workers in Qinghai Province to engage in non-discriminatory behaviors towards HBV-infected patients
ObjectiveTo understand the current status of primary healthcare workersâ knowledge of hepatitis B and their willingness to engage in non-discriminatory behaviorsï¼ to explore the factors influencing their willingnessï...