Characteristics of the Pseudomonas aeruginosa PA01 Intercellular Signaling Pathway (Quorum Sensing) Functioning in Presence of Porphyrins Bismuth Complexes
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 2
Abstract
The influence of synthetic and natural porphyrins bismuth complexes on [i]P. aeruginosa[/i] quorum sensing system was carried out by detection of the pyocyanin, rhamnolipids and autoinducers biosynthesis level. The highest ability to reduce pyocyanin biosynthesis showed Bi(III)-TPP. Rhamnolipids production level also decreased in the presence of studied compounds. This effect was the most expressed in presence of 40 and 80 μM of the synthetic meso-substituted porphyrins. Autoinducers biosynthesis, especially 3-oxo-C[sub]12[/sub]-HSL was suppressed in presence of the bismuth complexes. That suggest that the mechanisms of action of this substances is an inhibition of signaling molecules or/and receptor for them.
Authors and Affiliations
Mycola B. Galkin, Volodimir O. Ivanitsia, Yuriy V. Ishkov, Boris M. Galkin, Tetiana O. Filipova
Keywords
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