Characterization of acute adverse-effect profi le of carbamazepine and valproate in the grip-strength test in mice
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2008, Vol 2, Issue 1
Abstract
The aim of this study was to assess the acute adverse (neurotoxic) effects of two conventional antiepileptic drugs (carbamazepine and valproate) in the grip-strength test by measuring skeletal muscular strength in mice. Linear regression analysis of dose-response relationship for drug doses and their corresponding skeletal muscular strength allowed the determination of the doses of carbamazepine and valproate that reduced the grip-strength in mice by 50%, as compared to control mice. The experimentally-derived strength reducing dose by 50% for carbamazepine was 80.8 mg/kg, and that for valproate – 501.2 mg/kg. Based on this preclinical study, one can conclude that carbamazepine and valproate reduced in a dose-dependent manner skeletal muscular strength in mice. The grip-strength test can be applied as a paradigm for the evaluation of acute adverse-effect (neurotoxic) profile of drugs with respect to their influence on muscular strength in experimental mice.
Authors and Affiliations
Jarogniew Łuszczki, Anna Zadrożniak, Aleksandra Wlaź, Marta Andres-Mach, Monika Dudra-Jastrzębska, Jakub Zwoliński, Marcin Sielski
Keywords
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