CHARACTERIZATION OF HIGH ACTIVITY DRUG-STIMULATED ATPase OF MULTIDRUG RESISTANT LEISHMANIA DONOVANI AMASTIGOTE CELLS
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2015, Vol 4, Issue 6
Abstract
Background: The emergence of drug resistance and the limited knowledge of the mechanisms by which the parasites acquire resistance are the major obstracle for the control of leishmaniasis. Methods: The present investigation is aimed to study multidrug resistance related ATPase activity in in vitro generated sodium stibogluconate (SSG) and paramomycin (PMM) resistant Leishmania donovani amastigote permeablized by digitonin Results: The results of the multidrug resistance related ATPase activity in SSG and PMM resistant L.donovani amastigotes revealed that ATPase activities were strongly stimulated by resistance causing drugs, and these ATPase stimulation activities had broad specificities. Conclusion: Generation of drug resistance in L. donovani amastigotes leads to concurrent development of drug-stimulated ATPase activity.
Authors and Affiliations
Chowdhury S| Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India, Roy A| Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India, Kar N| Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India, Chakraborty S| Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India, Bera T| Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
Keywords
Related Articles
- EP ID EP16032
- DOI -
- Views 344
- Downloads 17
Potential Therapeutic use of Streblus asper: A Review
Streblus asper (Family: Moraceae) is a small tree which mainly located in India, Thailand, Malaysia and Philippines. Generally, it is usually known as Sihor (Hindi), Sheora (Bengali), Pitaphalaka (Sanskrit) and Piraaya...
Production of Rifamycin using Nocardia mediterranea (ATCC 13865)
The U.V. irradiation to Nocardia mediterranea ATCC 13865 for 10, 20, 30, 40, 50, 60, 70, up to 120 minute the maximum (581µgml-1) production of rifamycin was found developed S-10 strain for maximum production of rifam...
STUDY ON EFFECTS OF CARBAMAZEPINE AND PHENYTOIN ON DEVELOPMENT OF CHICK EMBRYO
The knowledge about the Teratogenic drugs is crucial while prescribing medications to the pregnant women. Treating epileptic pregnant women is always challenge as most of antiepileptic drugs are potent teratogens and th...
PHARMACOLOGICAL INVESTIGATION OF LEAVES OF ANTHOCEPHALUS CADAMBA (ROXB) FOR HEPATOPROTECTIVE ACTIVITY
The objective of the present investigation was to study hepatoprotective activity of ethanolic extract of leaves of Anthocephalus cadamba, paracetamol induced liver damage model in rats. In this study, liver damage in r...
Effect of Yogic exercise on static Spirometery values in normal healthy individuals
Introduction: Yogic practices can be a very good exercise for maintaining proper health and has a profound effect on the lung functions of an individual. They are also used as psycho-physiological stimuli to increase t...