Charakterystyka mocy poszczególnych wiązań wodorowych w parach zasad DNA

Journal Title: Wiadomości Chemiczne - Year 2019, Vol 73, Issue 1

Abstract

The main idea of the current review is to present methods useful to characterize the strength of individual hydrogen bonds in nucleic acids base-pairs. In the paper, the Authors discuss the energy definition of intermolecular interactions taking into account the presence of one intermolecular hydrogen bond (HB) as well as the situation when several intermolecular interactions (namely intermolecular hydrogen bonds) are present. In the Section 2 of the review a general overview of methods developed to estimate the strength of the individual intermolecular hydrogen bond in DNA/RNA base-pairs is presented. Thus, the reader can find detailed information on the methods used so far: the rotational method (2003), compliance constants method (2004), the EML equation application (2006), the atom replacement method (2007), the estimation of hydrogen bond energy on the basis of electron density (calculated by using the AIM theory) at BCP values (2009), the application of NBO method (2010), the comparison of HB strength based on the last two approaches (2015) and the application of coordinates interaction approach (2017). It should be emphasized, that these methods allow to estimate the strength of intermolecular interactions both in the model base-pairs and in other systems with several intermolecular hydrogen bonds. The discussion of the presented methods is supported by Tables 1-10, containing numerical values characteristics of the strength of the particular HB, and Figures 1–2. The section 3 contains a critical comparison of results based on the presented methods. Concluding remarks are given in the last Section.

Authors and Affiliations

Halina Szatyłowicz, Nina Sadlej-Sosnowska, Aneta Jezierska

Keywords

Related Articles

Wykorzystanie reakcji 1,3-dipolarnej cykloaddycji Huisgena do modyfikacji nukleozydów i ligonukleotydów

The 1,3-dipolar cycloaddition reaction between azides and terminal alkynes, known as the Huisgen reaction, constitutes a powerful tool for the synthesis of versatile molecules containing carbon – heteroatom bond. The use...

Nowe spojrzenie na efekt podstawnikowy

Classical view on the substituent effect (SE) is associated with an empiric approach presented 80-years ago by Hammett [1]. He proposed a simple formula to represent the effect of a substituent upon the rate or equilibri...

Synteza i aktywność biologiczna pochodnych pirolo[2,3-d]pirydazyny

Pyrrolo[2,3-d]pyridazines are one of the four structural isomers of the bicyclic ring system containing pyrrole moiety condensed with a pyridazine ring. This review presents most of the literature data about synthetic py...

Reakcje utleniania wybranych grup funkcyjnych z wykorzystaniem oxone® jako źródła tlenu cząsteczkowego

generation. Peroxymonosulfuric acid is one of the strongest oxidants. It was described for the first time in 1898 by Heinrich Caro. Nowadays, the commercial sources of KHSO5are low-cost industrial bulk chemicals, e.g., t...

Download PDF file
  • EP ID EP566741
  • DOI -
  • Views 199
  • Downloads 0

How To Cite

Halina Szatyłowicz, Nina Sadlej-Sosnowska, Aneta Jezierska (2019). Charakterystyka mocy poszczególnych wiązań wodorowych w parach zasad DNA. Wiadomości Chemiczne, 73(1), 53-74. https://europub.co.uk/articles/-A-566741