Chemical Constitution, In-silico Molecular Docking Studies and Antibacterial Activity of Flower Essential Oil of Artabotrys hexapetalus
Journal Title: Jordan Journal of Pharmaceutical Sciences - Year 2022, Vol 15, Issue 3
Abstract
The isolation of the volatile constituents from the flowers of Artabotrys hexapetalus was carried out using a simple headspace solvent-trapping technique and identified by GC-MS analysis. The major compounds are ethyl acetate 53.6%, isobutyl acetate (29.4%) and ethyl benzoate (14.2%). The odour of the solution obtained from this method was found to be similar to that of the fresh flowers. Further the essential oil from A. hexapetalus was obtained for the first time from India by hydro distillation using a Clevenger type apparatus and analysed by GC-MS. The plant yielded 1.26%, of the essential oils from the flower. The analysis lead to the identification of 28 compounds representing 96.17% of the total oil. The essential oil consists of predominantly oxygenated sesquiterpenes (51.91%) followed by sesquiterpenes (43.31%) and small quantities of monoterpenes (1.24%) and other compounds (1.34%). The main constituents of the essential oil obtained from the flowers of A.hexapetalus are β-caryophyllene (18.69%), caryophyllene oxide (14.54%), cubenol (12.53%) and ledol (11.5%). The essential oil showed antibacterial activity against bacterial strains Streptococcus pneumonia, Staphylococcus aureus, Streptococcus pyogenes and Pseudomonas aeruginosa exhibiting a zone of inhibition of 16.4, 15.7, 17.5 and 14.5 mm and MIC value of 2.5, 5.0, 2.5, 5.0 mg/ml respectively. Molecular docking analysis indicated that the essential oil constituents are nucleic acid and cell wall synthesis inhibitors. So it is worth to include this in cosmetics and fragrances.
Authors and Affiliations
S. Sowndhariya Sowndhariya, S. Ravi, J. Dharani Dharani, R. Sripathi Sripathi
Keywords
Related Articles
- EP ID EP711677
- DOI -
- Views 22
- Downloads 0
Phytochemical screening and in vitro antioxidant activity analysis of leaf and callus extracts of Allophylus serratus (ROXB) KURZ.
Allophylus serratus is an important medicinal plant whose leaves, fruits, roots and stem have been in use in traditional medicines. The present study is aimed to carry out preliminary phytochemical analysis and to deter...
Public Perception of Pharmacist's Role during COVID-19 Outbreak in Jordan
Background: The pandemic COVID-19 requires collaborative teamwork by all healthcare professionals including Pharmacists who could help in combating epidemic diseases by providing several pharmaceutical services. Neverth...
Studying the Effect of Functional Group and Size of Silica Nanoparticles Loaded with Quercetin on their in vitro Characteristics
Silica nanoparticles (SNs) possess unique properties making them ideal carriers for many agents. Both the size and the surface chemistry are important features that impact the in vitro characteristics of their loaded ag...
A Comparative Cross-Sectional Study- Knowledge, behavior and psychological change among Medical and Non-medical Students in Jordan during COVID-19 pandemic
Background: Coronavirus disease 2019 (COVID-19) has rapidly spread worldwide, and it was officially declared to be a pandemic by the World Health Organization on March 11, 2020. COVID-19 is associated with increasing mo...
A study on antibacterial efficacy of different extracts of Artocarpus chama fruits and identification of bioactive compounds in the most potent extract
This study is designed to evaluate the antibacterial potential of various extracts of mature green fruits of Artocarpus chama with the identification of bioactive compounds. The antibacterial efficacy was tested against...