Chemofailure and chemoresistance in retinoblastoma.
Journal Title: IP International Journal of Ocular Oncology and Oculoplasty - Year 2017, Vol 3, Issue 1
Abstract
Retinoblastoma (RB) is the most common malignant intraocular tumor in children constituting 4% of all pediatric cancers. (1) RB1 gene mutation affects the developing retina resulting in this malignant tumor which is mostly diagnosed in infancy or in early childhood. The current management protocol employs chemotherapy as the primary modality for management of retinoblastoma. (2) Tumor response to chemotherapy has increased the chances of cure manifold and the overall 3-year survival rate has increased to more than 90%.(3) Chemotherapeutic drugs induce tumor regression and reduce tumor volume, thereby allowing effective control using focal therapies.(4) The multimodal management of RB involving chemotherapy and focal treatment aim to preserve globe with functional vision(5) and avoid the morbidities associated with external beam radiation(6) and enucleation.
Authors and Affiliations
Rajarathna Thangavel, Sahithya Bhaskaran, Hakan Demirei
Keywords
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- EP ID EP291983
- DOI 10.18231/2455-8478 .2017.0002
- Views 79
- Downloads 0
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